Measurement of advanced MRI-based surrogate biomarkers in 5 regionsa

RegionADC (×10−3 mm2/s)rCBVKtrans (min−1)ve
Normal brain stem (n = 17)0.75 ± 0.041.36 ± 0.21NANA
Peritumoral edema (n = 22)1.42 ± 0.27b1.04 ± 0.31b0.0028 ± 0.00200.0035 ± 0.0030
Non-necrotic T2HrF (n = 16)1.48 ± 0.41b,c1.38 ± 0.68c,d0.0034 ± 0.0025c,d0.0057 ± 0.0042
T2HoF (n = 13)0.82 ± 0.16d,e3.82 ± 1.32b,e0.0112 ± 0.0071e0.0163 ± 0.0184e
Necrotic T2HrF (n = 9)1.47 ± 0.23b3.61 ± 1.63b,e0.0108 ± 0.0072e0.0171 ± 0.0132e

  • Note:—NA indicates not applicable.

  • ↵a Mean values ± SD are shown. Statistical differences between groups (P < .05) are signified as follows:

  • ↵b Normal brain stem.

  • ↵c T2HoF.

  • ↵d Necrotic T2HrF.

  • ↵e Edema.