Table 2:

Areas of significantly (P_uncorrected < .001) reduced cortical perfusion in RRMS subgroups and healthy controls, with volumes for atrophied regions added as covariates

qCBF	qCBV	Anatomic Regions	Cluster Size	MNI Coordinates			t Values
qCBF	qCBV	Anatomic Regions	Cluster Size	x	y	z	HC vs CI	HC vs NI	NI vs CI
✓	✓	Left superior frontal gyrus (BAs 6, 10)^{^a}	78	−32	50	28	3.52		3.62
✓		Right middle frontal gyrus (BA 6)^{^a}	26	34	0	64	3.31
✓	✓	Left middle frontal gyrus (BAs 10, 11, 46)^{^a}	100	−22	56	26	4.79	4.56	3.21
	✓	Left inferior frontal gyrus (BA 46)	21	−48	30	20			3.29
	✓	Right parahippocampal gyrus (BA 28)^{^a}	27	24	−22	−12	4.15
✓	✓	Right lingual gyrus^{^a}	101	12	−72	−2			5.11
✓		Left lingual gyrus (BA 18)	72	−6	−68	2			3.99
	✓	Right inferior parietal lobule (BA 40)^{^a}	22	48	−40	56			3.98
✓		Right superior temporal gyrus (BA 38)	38	28	10	−46		3.64
	✓	Left temporal fusiform gyrus (BA 20)^{^a}	134	−44	−22	−30			3.74
✓		Left caudate head^{^a}	36	−10	6	4			3.64
✓		Right caudate body	24	18	−20	26			3.68
✓		Left thalamic medial dorsal nuclei^{^a}	31	−6	−18	6			3.63

Note:—CI indicates patients with RRMS with cognitive impairment; NI, patients with RRMS without impairment; ✓, anatomic region was present in VBM analysis for this map.
↵a Anatomic regions remained significant from previous VBM analysis without atrophy areas added as covariates.