Intraclass correlation coefficients for 2D-SE and 3D-GE subcortical volume estimates using FreeSurfer and FIRSTa
| FreeSurfer Software | FIRST Software | ||
|---|---|---|---|
| Structure | ICC | Structure | ICC |
| Estimated TIV | 0.942 | R caudate | 0.914 |
| Subcortical gray volume | 0.93 | L caudate | 0.899 |
| R thalamus | 0.903 | L hippocampus | 0.864 |
| Brain stem | 0.865 | R thalamus | 0.85 |
| L putamen | 0.861 | L putamen | 0.826 |
| L caudate | 0.833 | R putamen | 0.815 |
| R putamen | 0.82 | R hippocampus | 0.814 |
| L ventral diencephalon | 0.801 | Brain stem | 0.784 |
| R ventral diencephalon | 0.765 | L pallidum | 0.781 |
| R pallidum | 0.762 | L thalamus | 0.773 |
| R caudate | 0.743 | R pallidum | 0.605 |
| L thalamus | 0.737 | R amygdala | 0.456 |
| L pallidum | 0.71 | L amygdala | 0.406 |
| R accumbens | 0.694 | L accumbens | 0.25 |
| R hippocampus | 0.654 | TIVb | 0.175 |
| R cerebellum cortex | 0.616 | R accumbens | 0.009 |
| L cerebellum cortex | 0.579 | ||
| L hippocampus | 0.568 | ||
| L accumbens | 0.511 | ||
| R amygdala | 0.397 | ||
| L amygdala | 0.321 | ||
Note:—L indicates left; R, right.
↵a The ICCs for 2D-SE and 3D-GE subcortical volume estimates using FreeSurfer and FIRST are shown. The ICC values are grouped in 5 categories: 33.3% and 43.8% of the structures with an almost perfect agreement using FreeSurfer and FIRST respectively, 42.9% and 25% of the structures with a substantial agreement using FreeSurfer and FIRST respectively, 14.3% and 12.5% of the structures with a moderate agreement using FreeSurfer and FIRST respectively, 9.5% and 6.25% of the structures with a fair agreement using FreeSurfer and FIRST respectively, and 0% and 12.5% of the structures with a slight agreement using FreeSurfer and FIRST respectively.
↵b FIRST total intracranial volume was calculated with the following formula: (FIRST template volume/matrix determinant) × 1000.