Table 3:

Clinicoradiologic correlation using 3D-GE and 2D-SE normalized subcortical structure values obtained with FreeSurfer software

Subcortical Structure	FreeSurfer 3D-GE				FreeSurfer 2D-SE
	Disease Duration		EDSS		Disease Duration		EDSS
	r	P	ρ	P	r	P	ρ	P
Brain stem	−0.258	.123	−0.408^{^a}	.012^{^a}	−0.143	.400	−0.545^{^a}	<.001^{^a}
L thalamus	−0.249	.137	−0.268	.109	−0.301	.070	−0.313^{^b}	.059^{^b}
L caudate	−0.304^{^b}	.068^{^b}	−0.285^{^b}	.088^{^b}	−0.316^{^b}	.057^{^b}	−0.283	.090
L putamen	−0.443^{^a}	.006^{^a}	−0.494^{^a}	.002^{^a}	−0.466^{^a}	.004^{^a}	−0.510^{^a}	.001^{^a}
L pallidum	−0.489^{^a}	.002^{^a}	−0.409^{^a}	.012^{^a}	−0.315^{^b}	.057^{^b}	−0.404^{^a}	.013^{^a}
L hippocampus	−0.191	.256	−0.122	.472	−0.144	.397	−0.085	.615
L amygdala	−0.083	.627	−0.335^{^a}	.043^{^a}	0.001	.997	−0.141	.404
L accumbens	−0.332^{^a}	.045^{^a}	−0.418^{^a}	.010^{^a}	−0.358^{^a}	.030^{^a}	−0.096	.571
R thalamus	−0.409^{^a}	.012^{^a}	−0.402^{^a}	.014^{^a}	−0.386^{^a}	.018^{^a}	−0.376^{^a}	.022^{^a}
R caudate	−0.455^{^a}	.005^{^a}	−0.365^{^a}	.02^{^a}	−0.29^{^b}	.074^{^b}	−0.230	.171
R putamen	−0.505^{^a}	.001^{^a}	−0.490^{^a}	.002^{^a}	−0.472^{^a}	.003^{^a}	−0.494^{^a}	.002^{^a}
R pallidum	−0.459^{^a}	.004^{^a}	−0.395^{^a}	.016^{^a}	−0.220	.192	−0.28^{^b}	.093^{^b}
R hippocampus	−0.262	.118	−0.302^{^b}	.069^{^b}	−0.238	.157	−0.220	.190
R amygdala	−0.181	.285	−0.294^{^b}	.077^{^b}	−0.183	.279	−0.323^{^b}	.051^{^b}
R accumbens	−0.330^{^a}	.046^{^a}	−0.416^{^a}	.011^{^a}	−0.215	.202	−0.216	.199

Note:—r indicates the Pearson correlation coefficient; ρ, the Spearman correlation coefficient; L, left; R, right.
↵a Significant correlations.
↵b Trend toward a significant correlation.