Details of LAST₂ CH₂ANCE

Symbol	Meaning	Details
L	Large vessel occlusion	Internal carotid artery or proximal MCA^{^a}
A	Age	≥18 yrs^{^a}
S	Symptom	NIHSS score ≥6^{^a}
T	Time	Onset to groin puncture time <6 h^{^a}
T₂	Thrombocytopenia	PLT ≥40*10⁹/L^{^b}
C	Crippled/disabled	mRS <2^{^a}
H	Hypoglycemia	CBG ≥2.7 mmol/L^{^b}
H₂	Hypertension	BP ≤185/110 mmHg^{^b}
A	Anticoagulation	INR ≤3.0^{^b}
N	Nonsalvageable brain tissue	ASPECTS ≥6^{^a}
C	Collateral	ACG >1^{^c}
E	Expectancy of life	>90 d^{^b}

Note:—ACG indicates American Society of Interventional and Therapeutic Neuroradiology collateral grading; BP, blood pressure; CBG, capillary blood glucose; INR, international normalization ratio; PLT, platelet count.
↵a Criterion from the American Heart Association/American Stroke Association guidelines.
↵b Criterion from the protocol of MR CLEAN trial.
↵c Criterion we use in our daily practice but without consensus in the literature.