Angiographic outcomes and treatment-related complications
Variables | Raw Numbersa | No. of Articles | 95% CI | I2 | P Value |
---|---|---|---|---|---|
MCA aneurysm occlusion after flow diversion | |||||
Overall rate of complete/near-complete occlusion | 137/171 = 78.7% | 10 | 67.8–89.7 | 76.24 | <.001 |
Factors related to aneurysm occlusion | |||||
Mean age (yr) | .262 | ||||
Complete/near-complete occlusion | 53.6 yr | 4 | 47.3–59.8 | 75% | |
Incomplete occlusion | 61.3 yr | 48.9–73.5 | 95% | ||
Mean size | .614 | ||||
Complete/near-complete occlusion | 7 mm | 6 | 3.6–10.3 | 83.6% | |
Incomplete occlusion | 5.5 mm | 0.8–10.1 | 99% | ||
Complete/near-complete occlusion | .38 | ||||
Retreatment | 64% | 5 | 33.9–93.4 | 75.2% | |
vs | vs | ||||
First treatment | 73% | 63–83.5 | 0% | ||
Complete/near-complete occlusion | .307 | ||||
Prebifurcation (M1–early cortical branches) | 88.1% | 11 | 79.6–96.7 | 0% | |
vs | vs | ||||
Bifurcation aneurysms | 77.7% | 64.5–89.5 | 74.92% | ||
Complications related to treatment and outcome | |||||
Overall rate of treatment-related complications | 46/213 = 20.7% | 11 | 14–27.5 | 34.03% | .126 |
Transient or asymptomatic | 11.3% | 7.6–16.2 | |||
vs | vs | 11 | 6.8–15.2 | ||
Permanent | 10.3% | ||||
Type of complications | |||||
Ischemic/thromboembolic | 16.3% | 11 | 10.1–22.6 | 36.65% | .106 |
Hemorrhagic | 2% | 0.2–3.9 | 0% | .958 | |
Iatrogenic (dissection/perforation) | 1.8% | 0%–1.3.5% | 0% | .973 | |
Perianeurysmal inflammation | 2.6% | 0.5–4.7 | 0% | .997 | |
Complications related to discontinuation of antiplatelet therapy | 4/46 = 8.7% | 11 | 2.9–20.8 | ||
Aneurysm rupture after treatment | 1/214 = 0.47% | 12 | 0.1–2.8 | ||
Overall rate of good outcome | 125/135 = 92.7% | 7 | 86.4–99.1 | 42.08% | .11 |
Mortality rate | 4/213 = 2% | 11 | 0.2–3.9% | 0% | .929 |
Note:— vs indicates versus.
↵a Results of meta-analysis.