Summary of clinical documentation of CHARGE diagnosis for the 10 subjects according to the criteria set by Verloes⁸

	Subject
	1	2	3	4	5	6	7	8	9	10
Sex	M	M	F	F	M	M	M	M	F	F
Age at MRI (yr)	1	2	18	1	1	7	4	8 mo	1	19
Major criteria
Coloboma		+	+			+			+	+
Choanal atresia						+			+
SCC hypoplasia	+	+	+	+	+	+	+	+	+	+
Minor criteria
Rhombencephalic dysfunction	+^1,2	+^1,2	+¹	+^1,2	+^1,2	+¹	+¹	+²	+^1,2
Hypothalamohypophyseal dysfunction	+³	+⁴		+⁴	+³	+⁴		+⁴	+⁴
Malformation of ear	+^5,6	+⁶	+⁶	+^5,6	+⁶	+⁶	+⁶	+⁶	+⁶	+⁶
Malformation of mediastinum	+⁷	+⁷		+⁷	+⁷	+⁷		+⁷	+^7,8	+⁷
Mental retardation	+	+		+	+			+
Typical CHARGE		+	+			+			+	+
Atypical CHARGE	+			+	+		+	+

Note:— + indicates present criteria; +¹, cochlear nerve hypoplastic or absent; +², brain stem hypoplasia; +³, undescended testes; +⁴, growth delay; +⁵, external ear malformation; +⁶, inner ear malformation; +⁷, cardiac malformation; +⁸, tracheoesophageal fistula.