Univariate analysis of categorical variables on prenatal MRI
| Categorical Variable | Control (n = 32) | AS (n = 43) | Adjusted P Value | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) |
|---|---|---|---|---|---|---|---|
| Enlarged inferior 3rd ventricular recesses | 1 (3.1%) | 31 (72%) | <.0023a | 72 (56–85) | 97 (84–100) | 97 (84–100) | 72 (56–85) |
| Lateral ventricular diverticulum | 1 (3.1%) | 15 (35%) | .0276a | 35 (21–51) | 97 (84–100) | 94 (70–100) | 53 (39–66) |
| Callosal thinning and/or dysgenesis | 16 (50%) | 40 (93%) | <.0023a | 93 (81–99) | 50 (32–68) | 71 (58–83) | 84 (60–97) |
| Aqueductal funneling | 0 (0%) | 9 (21%) | .1909 | 21 (10–36) | 100 (89–100) | 100 (60–100) | 48 (36–61) |
| Blood in the aqueduct | 0 (0%) | 3 (7%) | 1 | 7.0 (1.5–19) | 100 (89–100) | 100 (29–100) | 44 (33–57) |
| Rhombencephalosynapsis | 0 (0%) | 4 (9.3%) | 1 | 9.3 (2.6–22.1) | 100 (89–100) | 100 (40–100) | 45 (33–57) |
| Cerebellar dysplasia | 0 (0%) | 7 (16%) | .4117 | 16 (6.8–31) | 100 (89–100) | 100 (59–100) | 47 (35–60) |
| Tectal plate thickening | 2 (6.3%) | 12 (28%) | .437 | 28 (15–44) | 94 (79–99) | 86 (57–98) | 49 (36–62) |
| Intracranial hemorrhage | 2 (6.3%) | 15 (35%) | .1035 | 35 (21–51) | 94 (79–99) | 88 (64–99) | 52 (38–65) |
| Enlarged ventricular temporal horns | 20 (63%) | 40 (93%) | .0575 | 93 (81–99) | 38 (21–56) | 67 (53–78) | 80 (52–96) |
| Macrocephaly | 4 (13%) | 17 (40%) | .2484 | 40 (25–56) | 88 (71–96) | 81 (58–95) | 52 (38–66) |
| Cerebellar hypoplasia | 12 (38%) | 5 (12%) | .2714 | 12 (3.9–25) | 63 (44–79) | 29 (10–56) | 34 (22–48) |
| Vermian hypoplasia | 4 (13%) | 9 (21%) | 1 | 21 (10–36) | 88 (71–96) | 69 (39–91) | 45 (32–58) |
| Brain stem abnormality | 4 (13%) | 10 (23%) | 1 | 23 (12–39) | 88 (71–96) | 71 (42–92) | 46 (33–59) |
| Fourth ventricle dilation | 3 (9.4%) | 4 (9.3%) | 1 | 9.3 (2.6–22) | 91 (75–98) | 57 (18–90) | 43 (31–55) |
| Abnormal sulcation | 8 (25%) | 10 (23%) | 1 | 23 (12–39) | 75 (57–89) | 56 (31–78) | 42 (29–56) |
| Perforated septum pellucidum | 14 (44%) | 29 (67%) | 1 | 67 (51–81) | 56 (38–74) | 67 (51–81) | 56 (38–74) |
Note:—NPV indicates negative predictive value; PPV, positive predictive value; AS, aqueductal stenosis.
↵a Significant.