Table 1:

Global microstructural differences between children with CLN3 and age-matched control group with both skeleton and tractography approaches

MeasureControlCLN3 1stCLN3 2ndP Valuea (CLN3 1st vs Control)P Valuea (CLN3 2nd vs Control)P Valuea (CLN3 1st vs CLN3 2nd)
FA (skeleton).328 ± .026.297 ± .021.288 ± .029<.001b<.001b.95
FA (tractogram).271 ± .019.233 ± .016.224 ± .021.000001b.000001b.82
MD (skeleton).965 × 10−3 ± .0582 × 10−31.011 × 10−3 ± .0806 × 10−31.057 × 10−3 ± .119 × 10−3.01b.005b.89
MD (tractogram).957 × 10−3 ± .0506 × 10−31.036 × 10−3 ± .0882 × 10−31.108 × 10−3 ± .131 × 10−3<.001b<.001b.43
AD (skeleton)1.29 × 10−3 ± .0614 × 10−31.31 × 10−3 ± .0769 × 10−31.36 × 10−3 ± .112 × 10−3.12.04b.83
AD (tractogram)1.22 × 10−3 ± .0506 × 10−31.28 × 10−3 ± .0803 × 10−31.34 × 10−3 ± .122 × 10−3.008b<.001b.39
RD (skeleton).801 × 10−3 ± .0578 × 10−3.859 × 10−3 ± .0849 × 10−3.907 × 10−3 ± .126 × 10−3.003b.002b.93
RD (tractogram).823 × 10−3 ± .0512 × 10−3.917 × 10−3 ± .0927 × 10−3.990 × 10−3 ± .136 × 10−3<.001b<.001b.45
CP (skeleton).169 ± .0135.163 ± .0125.157 ± .0146.04b.03b.73
CP (tractogram).141 ± .0113.129 ± .00633.126 ± .00866<.001b<.001b.93

  • ↵a Age and sex were used as covariates.

  • ↵b Significant.