Table 3:

Longitudinal analysis controlling for T2LV and WBV^{^a}

Region	Model 1			Model 2			Change
Region	R²	P	P^{^b}	R²	P	P^{^b}	ΔR²	P	P^{^b}
Left thalamus	0.156	.000	.000	0.160	.000	.000	0.004	.181	.984
Right thalamus	0.141	.000	.000	0.147	.000	.000	0.006	.137	.984
Left caudate	0.067	.007	.028	0.074	.005	.020	0.007	.135	.984
Right caudate	0.084	.002	.014	0.092	.001	.008	0.008	.123	.984
Left putamen	0.146	.000	.000	0.164	.000	.000	0.018	.034	.340
Right putamen	0.055	.016	.036	0.130	.000	.000	0.075	.000	.000
Left globus pallidus	0.140	.000	.000	0.164	.000	.000	0.024	.017	.187
Right globus pallidus	0.152	.000	.000	0.161	.000	.000	0.009	.101	.909
Left hippocampus	0.102	.000	.000	0.097	.001	.008	−0.005	.729	1.00
Right hippocampus	0.098	.0001	.000	0.094	.001	.008	0.004	.590	1.00
Left amygdala	0.059	.012	.036	0.062	.012	.024	0.003	.207	.984
Right amygdala	−0.013	.711	.711	0.028	.106	.106	0.041	.005	.065
Left accumbens	0.070	.005	.025	0.104	.008	.024	0.034	.008	.096
Right accumbens	0.084	.002	.014	0.086	.002	.010	0.002	.240	.984

Note:—ΔWBV indicates change in whole-brain volume; ΔT2LV, change in T2 lesion volume.
↵a Hierarchic regression analyses predicting regional SGM 5-year atrophy. Predictors included in each model are as follows: model 1, age, sex, disease duration, ΔWBV, ΔT2LV, baseline tract disruption; model 2, age, sex, disease duration, ΔWBV, ΔT2LV, baseline tract disruption, longitudinal change in disruption of connected WM tracts.
↵b Holm-Bonferroni–corrected P values. All P values are significant.