Univariate linear mixed-effect models describing the longitudinal relationship between yearly change in clinical measures and lateral ventricle volume change in patients with MSa
| Patients with MS | LVV (mL) (n = 1465) | NBV (mL) (n = 1196) | PBVC (%) (n = 902) | |||
|---|---|---|---|---|---|---|
| Est | P Value | Est | P Value | P Value | P Value | |
| Intercept | 22.618 | 1513.318 | −.308 | |||
| DDY | 0.022 | .0001 | −0.426 | .0001 | −.025 | .0001 |
| Intercept | 22.43 | 1520.730 | −.263 | |||
| EDSS | 0.098 | .0001 | −2.187 | .0001 | −.134 | .0001 |
| Intercept | 22.065 | 1511.644 | −.214 | |||
| MSSS | 0.078 | .0001 | −2.001 | .0001 | −.119 | .0001 |
| DP-intercept | ||||||
| No | 23.137 | 1523.405 | −.125 | |||
| Yes | 0.485 | .0001 | −10.214 | .0001 | −.766 | .0001 |
| Difference | 0.591 | .0001 | −11.495 | .0001 | −.934 | <.0001 |
| +0.105 (21.6%) | .001 | −1.281 (−12.5%) | .03 | −.169 (−21.9%) | .0001 | |
Note:—Est indicates estimate; DDY, disease duration.
↵a Intercept as depicted in milliliters is the predicted value of the dependent variable when all the independent variables are restrained to zero. Estimate is a representation of the LVV volume increase and NBV volume decrease in milliliters per 1-unit increase of the independent measure per year (the interaction term with time). Estimate of PBVC is the representation of change in percentage per 1-unit increase of the independent measure per year (the interaction term with time). Volumetric (milliliters) data were fitted to random intercept and slope models, while PBVC models were fitted with random slope models.