Treatment-related outcomes after flow-diversion treatment of AcomA aneurysms
| Variables | Results of Systematic Review and Meta-Analysis | No. of Articles | Statistic (95% CI) (I2) |
|---|---|---|---|
| Angiographic outcomes | |||
| Rate of successful stent deployment | 142/145 = 95.5% | 13 | (92–98) (I2 = 0%) |
| Immediate aneurysm occlusion rate (OKM C–D) | 5/35 = 14% | 4 | (4–23) (I2 = 19%) |
| Long-term complete/near-complete occlusion rate (OKM C–D) | 91/105 = 87.4% | 10 | (81.3–93.6) (I2 = 0%) |
| Long-term complete occlusion rate (OKM D) | 66/80 = 84.9% | 8 | (76.8–93) (I2 = 12.5%) |
| Treatment-related complications and clinical outcomes | |||
| Overall treatment-related complications | 14/126 = 8.6% | 11 | (4–13.1) (I2 = = 0%) |
| Periprocedural/early complications (within 30 days) | 12/126 = 7% | 11 | (3–11) (I2 = 0%) |
| Delayed complications (after 30 days) | 2/126 = 1.8% | 11 | (1–5) (I2 = 0%) |
| Transient complications | 9/126 = 6% | 11 | (2.7–11) (I2 = 0%) |
| Permanent complications | 5/126 = 3.5% | 11 | (2–7) (I2 = 0%) |
| Treatment-related mortality | 2/148 = 2.5% | 14 | (0.3–5) (I2 = 0%) |
| Overall rate of good neurologic outcome | 108/114 = 95% | 10 | (93–98) (I2 = 0%) |
| Type of complications | |||
| Thromboembolic complications | 10/126 = 6% | 11 | (2–10) (I2 = 0%) |
| Hemorrhagic complications | 4/126 = 3% | 11 | (1–6) (I2 = 0%) |
| Acute in-stent thrombosis | 5/126 = 4% | 11 | (1.3–8) (I2 = 0%) |
| Aneurysm rupture after treatment | 0/138 = 0% | 13 | |
| Chronic in-stent stenosis (>50%) | 2/75 = 4.8% | 8 | (2–9) (I2 = 0%) |
| Overall flow changes on covered vessels | 12/34 = 28% | 4 | (1.5–5) (I2 = 76%) |
| Rate of narrowing of covered vessela | 5/34 = 11% | 4 | (0.7–20) (I2 = 8%) |
| Rate of occlusion of covered vesselsa | 7/34 = 16% | 4 | (3.5–28) (I2 = 22%) |
↵a Symptoms related to flow changes on the covered vessels (A2 or the recurrent artery of Heubner) were reported in 3 cases:1 case of transitory hemiparesis due slow flow on the covered A2; 1 case of transient facial palsy due to the coverage of the artery of Heubner; and 1 case of asymptomatic stroke in the territory of the artery of Heubner 4 months after treatment.