Clinical outcomes after subarachnoid hemorrhage: comparison between the antiplatelet and the control groups

OutcomesAntiplatelet Group vs Control Group (95% CI) (I2)No. of ArticlesP Value
Overall rate of delayed cerebral ischemia219/1060 vs 485/1762, OR = 0.781 (95% CI, 0.46–1.31) (I2 = 76.9%)7.33
Delayed cerebral ischemia endovascular group157/778 vs 413/1410, OR = 0.552 (95% CI, 0.273–1.115) (I2 = 80.1%)4.06a
Delayed cerebral ischemia surgical group42/195 vs 61/278, OR = 0.952 (95% CI, 0.288–3.147) (I2 = 79.5%)3.5
Delayed cerebral ischemia long-term ATb63/438 vs 96/353, OR = 0.379 (95% CI, 0.12–1.2) (I2 = 68%)3.06a
Delayed cerebral ischemia short-term ATc148/559 vs 349/1265, OR = 1.35 (95% CI, 0.81–2.23) (I2 = 80.1%)4.5
Cerebral vasospasm79/414 vs 84/327, OR = 0.52 (95% CI, 0.2–1.5) (I2 = 83%)2.2
Good outcome803/1144 vs 1175/1775, OR = 1.368 (95% CI, 1.117–1.676) (I2 = 9.3%)8.002a
Mortality79/672 vs 97/571, OR = 0.656 (95% CI, 0.47–0.91) (I2 = 0%)5.01a
Overall rate of complications40/438 vs 28/353, OR = 1.01 (95% CI, 0.34–3.01) (I2 = 42%)3.9
Overall rate of hemorrhagic complications32/438 vs 15/353, OR = 1.7 (95% CI, 0.89–3.38) (I2 = 1%)3.1
Overall rate of major hemorrhagic events8/438 vs 8/353, OR = 0.857 (95% CI, 0.32–2.28) (I2 = 10)3.7

  • ↵a Significant.

  • ↵b Long-term AT = AT for 3 or 4 weeks.

  • ↵c Short-term AT = AT for <2 weeks.