Table 2:

Results of multiple linear regression analysis

ParameterRegression Coefficient95% CIStandardized Regression CoefficientP Value
Globus pallidus-to-thalamus SI ratio changes
    Age−0.0001(−0.001–0.001)−0.019.853
    Sex0.003(−0.015–0.021)0.033.734
    Race−0.007(−0.019–0.005)−0.115.257
    EDSS−0.002(−0.006–0.002)−0.120.235
    DMT0.002(−0.002–0.005)0.104.298
    Interval between CE-MRIs<0.001(−0.002–0.002)0.002.986
    GBCA type0.001(−0.016–0.018)0.012.907
    No. of injections0.005(0.002–0.008)0.373.001
Substantia nigra-to-midbrain SI ratio changes
    Age0.001(0.000–0.002)0.144.136
    Sex0.030(0.004–0.056)0.211.023
    Race0.006(−0.012–0.023)0.064.500
    EDSS−0.003(−0.009–0.003)−0.088.352
    DMT−0.004(−0.009–0.001)−0.157.096
    Interval between CE-MRIs−0.001(−0.004–0.001)−0.106.271
    GBCA type0.022(−0.003–0.047)0.166.079
    No. of injections0.007(0.003–0.011)0.315.002
Dentate nucleus-to-middle cerebellar peduncle SI ratio changes
    Age0.0001(−0.001–0.002)0.023.828
    Sex−0.015(−0.050–0.020)−0.085.394
    Race−0.011(−0.035–0.012)−0.096.351
    EDSS−0.004(−0.012–0.004)−0.113.272
    DMT−0.004(−0.011–0.002)−0.129.205
    Interval between CE-MRIs−0.003(−0.006–0.001)−0.156.139
    GBCA type−0.002(−0.036–0.032)−0.012.909
    No. of injections0.006(0.000–0.012)0.216.049
  • Note:—CE indicates contrast-enhanced; DMT, disease-modifying therapy.