Lugano classification for CT-based lymphoma responsea
| Technique | Complete Response | Partial Response | No Response | PD |
|---|---|---|---|---|
| CT | Complete disappearance of disease or decrease in the lymph node long axis to <1.5 cm | Multiple: ≥ 50% decrease in SPD of up to 6 lesions. Single: ≥ 50% decrease in PPD | No criteria for PD and <50% decrease in SPD of up to 6 lesions. | (1) New or increased lymphadenopathy (long axis >1.5 cm): new nodes, ≥ 50% increase in PPD, or >0.5 cm increase in diameter for ≤2 cm or >1.0 cm for >2 cm; (2) splenic volume increase: with splenomegaly, >50% increase in length, or without splenomegaly, ≥2 cm increase in length; (3) new or larger lesions; (4) recurrent previously resolved lesions; (5) new extranodal lesion >1 cm (or <1 cm if unequivocally lymphoma) |
| FDG-PET/CT | D5PS score of 1, 2, or 3 in disease sites, with or without residual mass | D5PS score of 4 or 5, with reduced uptake compared with baseline | D5PS score of 4 or 5, with no signficant change in FDG uptake | D5PS score of 4 or 5, with increased uptake intensity compared with baseline and/or new FDG-avid foci |
Note:—SPD indicates sum of the product of the diameters (PPD).
↵a For non-FDG avid lymphomas, the following CT-based measurement criteria are used to determine tumor response classification; adapted from Ref. 15.