Table 3:

Microbleeds by location and white matter microstructure integrity^{^a}

	FA		MD		Axial Diffusivity		Radial Diffusivity
	β	P	β	P	β	P	β	P
None vs lobar
Model 1	−0.396 (−0.622 to −0.169)	.001	0.339 (0.135−0.543)	.001	0.270 (0.055−0.484)	.014	0.363 (0.159−0.566)	<.001
Model 2	−0.396 (−0.619 to −0.173)	.001	0.340 (0.138−0.541)	.001	0.270 (0.058−0.485)	.013	0.362 (0.162−0.563)	<.001
Model 3	−0.258 (−0.467 to −0.048)	.016	0.191 (0.010−0.372)	.038	0.131 (−0.065−0.327)	.191	0.215 (0.034−0.395)	.020
Model 4	−0.264 (−0.472 to −0.056)	.013	0.195 (0.014−0.376)	.034	0.134 (−0.062−0.330)	.180	0.218 (0.039−0.398)	.017
None vs deep
Model 1	−0.509 (−0.726 to −0.293)	<.001	0.530 (0.335−0.725)	<.001	0.486 (0.283−0.689)	<.001	0.534 (0.339−0.729)	<.001
Model 2	−0.481 (−0.697 to −0.266)	.001	0.512 (0.317−0.706)	<.001	0.472 (0.268−0.675)	<.001	0.514 (0.319−0.708)	<.001
Model 3	−0.244 (−0.450 to −0.038)	.020	0.243 (0.065−0.421)	.008	0.218 (0.028−0.408)	.025	0.246 (0.068−0.424)	.007
Model 4	−0.242 (−0.448 to −0.036)	.021	0.245 (0.071−0.424)	.007	0.220 (0.029−0.411)	.024	0.248 (0.069−0.426)	.007

Note:—β indicates regression coefficient.
↵a Values represent differences in z scores of mean FA, MD, axial diffusivity and radial diffusivity of NAWM for the presence of any microbleeds by their location compared with no microbleeds. Model 1: adjusted for age and sex; model 2: same as model 1, additionally adjusted for hypertension, hyperlipidemia, smoking, diabetes; model 3: adjusted for age, sex, lacunes, white matter hyperintensity volume (log-transformed); model 4: adjusted for sex, cardiovascular risk factors as in model 2, and CSVD imaging markers as in model 3.