Table 2:

Microbleeds (yes versus no) and white matter microstructure integritya

FAMDAxial DiffusivityRadial Diffusivity
βPβPβPβP
Model 1−0.450 (−0.616 to −0.285)<.0010.433 (0.282−0.584)<.0010.378 (0.221−0.535)<.0010.446 (0.295−0.597)<.001
Model 2−0.433 (−0.597 to −0.269)<.0010.420 (0.271−0.570)<.0010.368 (0.212−0.524)<.0010.432 (0.282−0.581)<.001
Model 3−0.238 (−0.394 to −0.083).0030.204 (0.068−0.340).0030.165 (0.019−0.310).0260.217 (0.081−0.352).002
Model 4−0.241 (−0.396 to −0.086).0020.206 (0.070−0.342).0030.167 (0.021−0.312).0250.218 (0.083−0.354).002
  • Note:—β indicates regression coefficient.

  • a Values represent differences in z scores of mean FA, MD, axial diffusivity, and radial diffusivity of NAWM for the presence of any microbleeds compared with no microbleeds. Model 1: adjusted for age and sex; model 2: same as model 1, additionally adjusted for hypertension, hyperlipidemia, smoking, diabetes; model 3: adjusted for age, sex, lacunes, and white matter hyperintensity volume (log-transformed); model 4: adjusted for sex, cardiovascular risk factors as in model 2, and CSVD imaging markers as in model 3.