Clinical features of patients with NCLa
| NCL Subtypes | Sex | Speech Delay n (%) | Visual Impairment n (%) | Seizures n (%) | Behavioral Abnormalities n (%) | Cognitive Decline n (%) | Developmental Regression n (%) |
|---|---|---|---|---|---|---|---|
| CLN1 disease (n = 6) | M (n = 4), F (n = 2) | 5 (83) | 5 (83) | 4 (67) | 3 (50) | 5 (83) | 5 (83) |
| CLN2 disease (n = 5) | M (n = 5) | 4 (80) | 3 (60) | 4 (80) | 2 (40) | 4 (80) | 4 (80) |
| CLN3 disease (n = 2) | M (n = 2) | 2 (100) | 2 (100) | 1 (50) | 2 (100) | 2 (100) | 2 (100) |
| CLN5 disease (n = 1) | F (n = 1) | 1 (100) | 1 (100) | 1 (100) | 1 (100) | 1 (100) | 1 (100) |
| CLN6 disease (n = 2) | M (n = 1), F (n = 1) | 1 (50) | 1 (50) | 1 (50) | 1 (50) | 2 (100) | 2 (100) |
| CLN7 disease (n = 6) | M (n = 4), F (n = 2) | 6 (100) | 2 (33) | 6 (100) | 2 (33) | 6 (100) | 6 (100) |
| CLN8 disease (n = 2) | M (n = 1), F (n = 1) | 2 (100) | 0 (0) | 2 (100) | 0 (0) | 2 (100) | 2 (100) |
↵a Data are number of patients (percentage in parenthesis).