Table 2:

Neuroradiologic findings in brain MR images in patients with Wolfram syndrome^{^a}

Radiologic Sign	First Visit (n = 30)	Last Visit (n = 30)
Negative PPBS sign^{^b}	16 (53)	21 (70)
T1/T2 pons signal abnormalities	16 (53)	20 (67)
Optic nerve atrophy	9 (30)	24 (80)^{^c}
White matter T2 hyperintensities^{^d}	8 (27)	10 (33)
Cerebellum atrophy	7 (23)	21 (70)^{^c}

↵a Numbers and percentages are reported.
↵b Absent and diminished PPBS sign.
↵c P value < .01 (χ² test).
↵d FLAIR images were not available to evaluate white matter T2 hyperintensity for 1 scan, and T2-weighted images were used instead.