Patient demographics, clinical presentation, and outcomes
| Clinical Parameter | Subgroups | Value |
|---|---|---|
| Maternal age | Mean age in years | 33.5 (27–39) |
| Gestational age at birth (weeks) | Term (≥37) | 11/16 |
| Moderate-to-late preterm (32–37) | 2/16 | |
| Very preterm (28–32) | 2/16 | |
| Extremely preterm (≤ 28) | 1/16 | |
| Sex | Male | 5/16 |
| Female | 11/16 | |
| Mode of delivery | Vaginal | 13/16 |
| Cesarean delivery | 3/16 | |
| Birth weight | <2.5 kg | 5/16 |
| >2.5 kg | 11/16 | |
| Mean | 2.2 kg | |
| Birth assistance in vaginal delivery | No assistance | 10/13 |
| Vacuum assistance | 3/13 | |
| Clinical presentation | Apnea | 10/16 |
| Seizure | 9/16 | |
| Encephalopathy | 3/16 | |
| APGAR score at 1 min | 6.3 (range, 1–9) | |
| APGAR score at 5 min | 8.4 (range, 4–9) | |
| Age at onset of symptoms | 2.1 days (range, 1–6 days of life) | |
| Age at most recent follow-up | 18.8 months (range, 1–90 months) | |
| Abnormal coagulation/hematology profile | Maternal | 0/16 |
| Neonatal | 1/16 (elevated hematocrit) | |
| Outcome | Death | 3/16 (1 extremely preterm, 2 very preterm) |
| With neurologic deficits | 2/16 | |
| No neurologic deficits | 11/16 |