Results of diagnostic performance of 2 neuroradiologists in the detection of changes of optic neuritis on T2-weighted FLAIR, coronal CE-T1WI, and axial CE-T1WI of brain without and with the availability of postprocessed images that aimed to selectively accentuate the signal intensity of diseased optic nerves
| Parameter | Reader 1 | Pa Value | Reader 2 | Pa Value | Average | |||
|---|---|---|---|---|---|---|---|---|
| Before Processing | After Processing | Before Processing | After Processing | Before Processing | After Processing | |||
| Sensitivity (FL) | 56.7% | 56.7% | .34 | 53.3% | 53.3% | .31 | 55.0% | 55.0% |
| Specificity (FL) | 62.1% | 89.7% | .01 | 89.7% | 93.1% | .5 | 75.9% | 91.4% |
| Accuracy (FL) | 59.3% | 72.9% | .03 | 71.2% | 72.9% | .5 | 65.3% | 72.9% |
| PPV (FL) | 60.7% | 85% | NA | 84.2% | 88.9% | NA | 72.5% | 86.9% |
| NPV (FL) | 58.1% | 66.7% | NA | 65% | 65.9% | NA | 61.5% | 66.3% |
| Sensitivity (CCE) | 47.8% | 56.5% | .31 | 56.5% | 56.5% | .24 | 52.2% | 56.5% |
| Specificity (CCE) | 81.8% | 100% | .07 | 95.5% | 100% | .5 | 88.7% | 100% |
| Accuracy (CCE) | 64.4% | 77.8% | .04 | 75.5% | 77.8% | .5 | 69.9% | 77.8% |
| PPV (CCE) | 73.3% | 100% | NA | 92.9% | 100% | NA | 83.1% | 100% |
| NPV (CCE) | 60% | 68.8% | NA | 67.7% | 68.8% | NA | 63.9% | 68.8% |
| Sensitivity (ACE) | 20.0% | 30.0% | .22 | 13.3% | 30.0% | .07 | 16.7% | 30.0% |
| Specificity (ACE) | 86.2% | 100% | .07 | 100% | 100% | 0 | 93.1% | 100.0% |
| Accuracy (ACE) | 52.5% | 64.4% | .04 | 55.9% | 64.4% | .07 | 54.2% | 64.4% |
| PPV (ACE) | 60% | 100% | NA | 100% | 100% | NA | 80.0% | 100% |
| NPV (ACE) | 51% | 58% | NA | 52.7% | 58% | NA | 51.9% | 58% |
Note:—FL indicates FLAIR; CCE, coronal CE-T1WI; ACE, axial CE-T1WI; NPV, negative predictive value; NA, not applicable.
↵a One-tailed McNemar test.