Clinicodemographic characteristics of the studied population, along with MR imaging–derived global brain volumesa
| Site 1 (n = 500) | Site 2 (n = 104) | P Value (Site 1 vs Site 2) | |
|---|---|---|---|
| Age (mean) (yr) | 37.5 (SD, 10.9) | 38.3 (SD, 9.8) | .49 |
| Female sex (No.) (%) | 349 (69.8) | 80 (76.9) | .16 |
| Secondary-progressive course (No.) (%) | 72 (14.4) | 20 (19.2) | .23 |
| DD (mean) (yr) | 9.3 (SD, 8.1) | 9.2 (SD, 8.5) | .83 |
| EDSS (median) (IQR) | 2.5 (2.0–4.0) | 2.0 (1.5–4.0) | .03 |
| TLV (mean) (mL) | 10.6 (SD, 13.4) | 7.2 (SD, 8.6) | .05 |
| WBV (mean) (mL) | 1026.1 (SD, 116.3) | 1042.6 (SD, 117.4) | .48 |
Note:—TLV indicates total lesion volume.
↵a Between-group differences regarding MR imaging measures are adjusted for age, sex, and estimated total intracranial volume.