Baseline characteristics
| Overall Cohort | |||
|---|---|---|---|
| 0–6 Hours (n = 205) | 6–24 Hours (n = 132) | P Value | |
| Variable | |||
| Age (median) (IQR) (yr) | 72 (61–80) | 75 (60–83) | .418 |
| Female | 104 (50.7%) | 71 (53.4%) | .584 |
| Baseline NIHSS (median) (IQR) | 18 (14–24) | 17 (11–22) | .045 |
| Premorbid mRS (median) (IQR) | 0 (0–1) | 0 (0–1) | .600 |
| Risk factors | |||
| Arterial hypertension | 157 (76.6%) | 106 (80.3%) | .421 |
| Type 2 diabetes | 60 (29.3%) | 38 (28.8%) | .924 |
| Dyslipidemia | 142 (69.3%) | 95 (72.0%) | .596 |
| Coronary artery disease | 54 (26.3%) | 34 (25.8%) | .905 |
| Atrial fibrillation | 90 (43.9%) | 47 (35.6%) | .130 |
| Chronic kidney disease | 47 (22.9%) | 37 (28.0%) | .290 |
| Ischemic stroke | 30 (14.6%) | 15 (11.4%) | .389 |
| Smoking (ever) | 115 (56.1%) | 70 (53.0%) | .581 |
| Site of occlusion | |||
| ICA | 41 (20.0%) | 34 (25.8%) | .427 |
| M1 | 127 (62.0%) | 78 (59.1%) | |
| M2 | 37 (18.0%) | 20 (15.2%) | |
| CT-ASPECTS (median) (IQR) | 9 (8–10) | 9 (7–10) | .005 |
| Transfer to CSC | 104 (50.7%) | 82 (62.1%) | .040 |
| IV-tPA | 117 (57.1%) | 18 (13.6%) | <.001 |
| Time to intervention (median) (IQR) | 204 (158–263) | 684 (476–919) | <.001 |
| Primary aspiration | 47 (22.9%) | 36 (27.3%) | .366 |
| TICI 2b/3 revascularization | 193 (94.1%) | 120 (90.9%) | .259 |
| sICH | 13 (6.3%) | 12 (9.1%) | .347 |
| Functional outcome | |||
| mRS 0–2 | 90 (43.9%) | 43 (32.6%) | .038 |
| mRS 6 | 58 (28.3%) | 25 (18.9%) | .052 |
Note:—CSC indicates comprehensive stroke center; sICH, symptomatic intracranial hemorrhage.