- Clinical Improvement after Shunt Surgery in Patients with Idiopathic Normal Pressure Hydrocephalus Can Be Quantified by Diffusion Tensor Imaging
This study investigated DTI parameter alterations in pre- and postshunt implantation in patients with iNPH and the relationship between DTI parameters and clinical improvement. Cognitive domain improvement after surgery correlated with preoperative DTI values of cingulate gyrus, uncinate fasciculus, superior longitudinal fasciculus, or corpus callosum, which are regions involved in memory and psychomotor speed processes.
- Prediction of Surgical Outcomes in Normal Pressure Hydrocephalus by MR Elastography
MR elastography allows noninvasive evaluation of mechanical properties of the brain altered by NPH. Different morphologic phenotypes of NPH are associated with unique mechanical signatures. Pattern analysis based on MRE is a promising method for improving diagnosis to distinguish NPH from other neurologic disorders that may have overlapping imaging and/or clinical presentations (such as Parkinson disease, Alzheimer disease, or progressive supranuclear palsy) and for predicting shunt outcomes.
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