- Absence of the Susceptibility Vessel Sign with Cancer-Associated Hypercoagulability-Related Stroke
Cancer-associated hypercoagulability-related stroke is presumably caused by fibrin-predominant thrombi and is associated with the absence of the susceptibility vessel sign (sensitivity of 90%/specificity of 78%/ likelihood ratio of 4.06). This is in contradistinction to cardioembolic erythrocyte-predominant thrombi, which demonstrate hypointense signal on T2-weighted gradient-recalled echo images (susceptibility vessel sign).
- Skull Base CSF Leaks: Potential Underlying Pathophysiology and Evaluation of Brain MR Imaging Findings Associated with Spontaneous Intracranial Hypotension
The purpose of this study was to use a validated brain MRI scoring system (Bern score) to evaluate patients with confirmed skull base CSF leaks for findings associated with SIH. The authors found that patients with skull base CSF leaks did not have brain MRI findings that are associated with SIH and likely have distinct pathophysiology from spinal CSF leaks.
- Glial Fibrillary Acidic Protein Astrocytopathy: Review of Pathogenesis, Imaging Features, and Radiographic Mimics
Glial fibrillary acidic protein (GFAP) astrocytopathy is a CNS autoimmune inflammatory disorder characterized by specific antibodies targeting the intracellular filament protein in mature astrocytes. Neuroimaging findings include linear perivascular enhancement in the white matter extending in a radial pattern, periependymal enhancement, longitudinally extensive cord signal changes, intramedullary enhancement, optic neuritis, and papillitis.
- An Optimized CT Protocol for Detecting Suspected Cauda Equina Syndrome: A Comparative Analysis with MRI
This study prospectively evaluated the diagnostic accuracy of an optimized CT lumbar spine protocol as a potential alternative to MRI in assessing suspected neural compression. CT accurately identified all cases requiring urgent decompression. CT had 97% sensitivity, specificity, and positive and negative predictive values in detecting disc pathology in patients presenting with symptoms suggestive of acute neural compression compared with MRI.
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