Endothelial Dysfunction: a Novel Therapeutic TargetSecondary Endothelial Dysfunction: Hypertension and Heart Failure
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2019, American Journal of CardiologyCitation Excerpt :Our findings are consistent with a previous META-analysis showing that the association between PRU and the risk of adverse ischemic outcomes was stronger among patients with versus without hypertension and other cardiovascular risk factors.11 Hypertension is association with endothelial inflammation and dysfunction.6–8 Given the central role of endothelial cells in suppressing platelet adhesion and maintaining normal platelet function, dysfunctional coronary endothelium would be expected to promote platelet adhesion and activation.4,5
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