Regular ArticleComparison of Impaired Subcortico-Frontal Metabolic Networks in Normal Aging, Subcortico-Frontal Dementia, and Cortical Frontal Dementia☆
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2017, Neurobiology of AgingCitation Excerpt :The hallmark topography of the PDD-PC2, which was correlated with age, was hypometabolism in the frontal polar region. This is in line with previous reports on frontal hypometabolism in normal aging (Curiati et al., 2011; Garraux et al., 1999; Kakimoto et al., 2016; Moeller et al., 1996; Nugent et al., 2014). Likewise, similar age-related changes have been reported in the amygdala (Curiati et al., 2011) and insula (Garraux et al., 1999; Nugent et al., 2014), which are also found to be hypometabolic in PDD-PC2.
Manifold learning on brain functional networks in aging
2015, Medical Image AnalysisCitation Excerpt :Second, our result suggests age-related functional disconnection between the subcortical and cortical structures, especially disconnection between subcortical and frontal structures, which is in line with converging data from positron emission tomography (PET), diffusion tensor imaging (DTI), and neurocognition in aging. Garraux et al. (1999) show subcortical-frontal metabolic impairment in normal aging. Westlye et al. (2010) suggest age-related disruptions in major fiber bundles connecting subcortical and cortical structures.
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Part of this study was presented at the Eighth Meeting of the European Neurological Society, June 1998, Nice, France.