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Immunohistochemical study of granular cell tumors of the neurohypophysis

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Virchows Archiv B

Summary

Six granular cell tumors (GCT) of the neurohypophysis were studied by immunohistochemical techniques. They were all labeled by peanut lectin (Arachis hypogaea) and three showed reactivity for S-100 protein. Unlike extracranial GCT, neuron specific enolase (NSE), myelin basic protein (MBP) and vimentin were not detected in the tumor cells. Glial fibrillary acidic protein (GFAP), keratin and desmin were also not observed. On the other hand, some showed reactivity for alpha-1 -antitrypsin (AAT), alpha-1-antichymotrypsin (AAC) and cathepsin B. These results suggest that neurohypophysial GCT have some features different from extracranial GCT and that they may not be derived from Schwann cells.

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Authors and Affiliations

  1. Bluestone Laboratory, Division of Neuropathology, Department of Pathology, Montefiore Medical Center, 111 East 210th Street, 10467, Bronx, NY, USA

    Hiroshi Nishioka, Kunio Ii, Josefina F. Llena & Asao Hirano

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  1. Hiroshi Nishioka
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  2. Kunio Ii
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  3. Josefina F. Llena
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  4. Asao Hirano
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Nishioka, H., Ii, K., Llena, J.F. et al. Immunohistochemical study of granular cell tumors of the neurohypophysis. Virchows Archiv B Cell Pathol 60, 413–417 (1991). https://doi.org/10.1007/BF02899574

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  • DOI: https://doi.org/10.1007/BF02899574

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