Summary
Combined injections of 3H-leucine and HRP were made into the monkey cerebellar cortex in order to identify any reciprocal connections between the corticonuclear and the nucleocortical pathways. These combined intraaxonal labeling experiments have demonstrated a considerable overlap of orthogradely labeled Purkinje cell axons and terminals with retrogradely labeled HRP-positive neurons in the ventrolateral region of the dentate nucleus following combined injections into the lateral hemisphere, and in the dorsal area of the dentate following combined injections into medial cortical areas of the anterior lobe. There were also areas within the deep cerebellar nuclei where orthogradely labeled corticonuclear terminals did not overlap with retrogradely labeled nucleocortical neurons.
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Allen, G.I., Tsukahara, N.: Cerebrocerebellar communication systems. Physiol. Rev. 54, 957–1006 (1974)
Allen, G.I., Gilbert, P.F.C., Yin, T.C.T.: Convergence of cerebral inputs onto dentate neurons in the monkey. Exp. Brain Res. 32, 141–170 (1978)
Chan-Palay, V.: Cerebellar dentate nucleus: Organization, cytology, and transmitters. Berlin, Heidelberg, New York: Springer 1977
Cowan, W.M., Gottlieb, D.I., Hendrickson, A.E., Price, J.C., Woolsey, T.A.: The autoradiographic demonstration of axonal connections in the central nervous system. Brain Res. 37, 21–51 (1972)
Eager, R.P.: Patterns and mode of termination of cerebellar corticonuclear pathways in the monkey (Macaca mulatta). J. Comp. Neurol. 126, 551–566 (1966)
Gould, B.B.: Topographic organization of the cerebellar nucleocortical projection in the cat. Anat. Rec. 187, 592 (1977)
Gould, B.B., Graybiel, A.M.: Afferents to the cerebellar cortex in the cat: evidence for an intrinsic pathway leading from the deep nuclei to the cortex. Brain Res. 110, 601–611 (1976)
Haines, D.E.: Cerebellar corticonuclear and corticovestibular fibers of the anterior lobe in a prosimian primate (Galago senegalenis). J. Comp. Neurol. 170, 67–96 (1976)
Haines, D.E.: Cerebellar corticonuclear-nucleocortical topography: A study of the tree shrew (Tupaia) paraflocculus. Anat. Rec. 190, 411 (1978)
Ito, M., Yoshida, M., Obata, K., Kawai, N., Udo, M.: Inhibitory control of intracerebellar nuclei by the Purkinje cell axons. Exp. Brain Res. 10, 64–80 (1970)
Jansen, J., Brodal, A.: Experimental studies on the intrinsic fibers of the cerebellum. II. The corticonuclear projection in the rabbit and the monkey (Macacus rhesus). Skrifter Norski Videnshaps Akad., Oslo I. Mat. Naturv. Kl. 3, 1–50 (1942)
McCrea, R.A., Bishop, G.A., Kitai, S.T.: Morphological and electrophysiological characteristics of projection neurons in the nucleus interpositus of the cat cerebellum. J. Comp. Neurol. 181, 397–419 (1978)
Thach, W.T.: Correlation of neuronal discharge with pattern and force of muscular activity joint position and direction of intended next movement in motor cortex and cerebellum. J. Neurophysiol. 41, 654–676 (1978)
Tolbert, D.L., Bantli, H., Bloedel, J.R.: Anatomical and physiological evidence for a cerebellar nucleo-cortical projection in the cat. Neuroscience 1, 205–217 (1976)
Tolbert, D.L., Bantli, H., Bloedel, J.R.: The intracerebellar nucleocortical projection in a primate. Exp. Brain Res. 30, 425–434 (1977)
Tolbert, D.L., Bantli, H., Bloedel, J.R.: Multiple branching of cerebellar efferent projections in cats. Exp. Brain Res. 31, 305–316 (1978a)
Tolbert, D.L., Bantli, H., Bloedel, J.R.: Organizational features of the cat and monkey cerebellar nucleocortical project. J. Comp. Neurol. 182, 39–56 (1978b)
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Tolbert, D.L., Bantli, H. An HRP and autoradiographic study of cerebellar corticonuclear-nucleocortical reciprocity in the monkey. Exp Brain Res 36, 563–571 (1979). https://doi.org/10.1007/BF00238523
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DOI: https://doi.org/10.1007/BF00238523