Skip to main content
Log in

Side effects after lumbar iohexol myelography

Relation to radiological diagnosis, sex and age

  • Originals
  • Published:
Neuroradiology Aims and scope Submit manuscript

Summary

Side effects of iohexol lumbar myelography have been analyzed with respect to the influence of the type of radiological abnormality, sex and age in a group of 200 patients. Headache, postural headache, nausea and back/leg pain were significantly more frequent in patients without definite radiological abnormalities. Postural headache, nausea, dizziness and mental symptoms were more frequent in women, while headache, postural headache, nausea, dizziness, minor mental symptoms (i. e. anxiety or depression) and pain became less frequent with age. This pattern is similar to that reported after lumbar puncture. Young women without definite clinical signs of nerve root lesions probably have the greatest risk of experiencing side effects after iohexol lumbar myelography.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Skalpe IO, Torbergsen T, Amundsen P, Presthus J (1973) Lumbar myelography with metrizamide. Acta Radiol [Suppl] 335: 367–379

    Google Scholar 

  2. Skalpe IO, Amundsen P (1975) Lumbar radiculography with metrizamide. Radiology 115: 91–95

    Google Scholar 

  3. Skalpe IO, Amundsen P (1975) Thoracic and cervical myelography with metrizamide. Radiology 116: 101–106

    Google Scholar 

  4. Hindmarsh T (1975) Lumbar myelography with meglumine iocarmate and metrizamide. Acta Radiol [Diagn] 16: 209–222

    Google Scholar 

  5. Ahlgren P (1975) Amipaque myelography. The side effects compared with Dimer X. Neuroradiology 9: 197–202

    Google Scholar 

  6. Rolfe EB, Maguire PD (1980) The incidence of headache following various techniques of metrizamide myelography. Br J Radiol 53: 840–844

    Google Scholar 

  7. Postacchini F, Massobrio M (1985) Outpatient lumbar myelography. Spine 10: 567–570

    Google Scholar 

  8. Nakstad P, Helgetveit A, Aaserud O, Ganes T, Nyberg-Hansen R (1984) Iohexol compared to metrizamide in cervical and thoracic myelography. Neuroradiology 26: 479–484

    Google Scholar 

  9. Lesak F (1986) Comparison of the side-effects of iohexol and metrizamide in lumbar myelography/radiculography. Ugeskr Laeger 148: 1206–1208

    Google Scholar 

  10. Shaw DD, Bach-Gansmo T, Dahlstrom K (1985) Iohexol: summary of North American and European clinical trials in adult lumbar, thoracic and cervical myelography with a new nonionic contrast medium. Invest Radiol [Suppl 1] 20: s44-s50

    Google Scholar 

  11. Skalpe IO, Nakstad P (1988) Myelography with iohexol (Omnipaque); A clinical report with special reference to the adverse effects. Neuroradiology 30: 169–174

    Google Scholar 

  12. Yu YL, du Boulay GH, Paul E (1986) Influence of certain factors on the manifestations of the adverse effects of metrizamide myelography. Neuroradiology 28: 339–343

    Google Scholar 

  13. Sand T, Stovner LJ, Dale L, Salvesen R (1987) Side effects after diagnostic lumbar puncture and lumbar iohexol myelography. Neuroradiology 29: 385–388

    Google Scholar 

  14. Dana CL (1917) Puncture headache JAMA 68: 1017

    Google Scholar 

  15. Tourtelotte WW, Haerer AF, Heller GL, Somers JE (1964) Post-lumbar puncture headaches. Thomas, Springfield, Illinois

    Google Scholar 

  16. Tourtelotte WW, Henderson WG, Tucker RP, Gilland O, Walker JE, Kokman E (1972) A randomized double-blind clinical trial comparing the 22 vs 26 G needle in the production of the post-lumbar puncture syndrome in normal individuals. Headache 12: 73–78

    Google Scholar 

  17. Nestvold K (1978) The influence of lumbar puncture needle size on postpuncture complications. Tidskr Nor Laegeforen 98: 569–570

    Google Scholar 

  18. Lange HU (1978) Angst und Neurotismus in der Genese von postpunktionellen Kopfschmerzen. Nervenarzt 49: 47–49

    Google Scholar 

  19. Hilton-Jones D, Harrad RA, Gill MW, Warlow CP (1982) failure of postural manoeuvres to prevent lumbar puncture headache. J Neurol Neurosurg Psychiatry 45: 743–746

    Google Scholar 

  20. Vilming ST, Schrader H, Monstad I (1988) Post-lumbar-puncture headache: The significance of body posture. Cephalalgia 8: 75–78

    Google Scholar 

  21. Vilming ST, Schrader H, Monstad I (1989) The significance of age, sex and initial cerebrospinal fluid pressure in postlumbar-puncture headache. Cephalalgia (in press)

  22. Herkowitz HN, Romeyn R, Rothman RH (1983) The indications for metrizamide myelography. J Bone Joint Surg 65-A: 1144–1149

    Google Scholar 

  23. Simon JH, Ekholm SE, Kido DK, Utz R, Erickson J (1987) High-dose iohexol myelography. Radiology 163: 455–458

    Google Scholar 

  24. Sand T, Myhr G, Stovner LJ, Dale LG, Tangerud Å (1989) Side effects after ambulatory lumbar iohexol myelography. Neuroradiology 31: 49–54

    Google Scholar 

  25. Armitage P (1971) Statistical methods in medical research. Blackwell, Oxford London Edinburgh Melbourne, pp 129–131

    Google Scholar 

  26. Sand T (1989) Which factors affect reported headache incidences after lumbar myelography? Neuroradiology 31: 55–59

    Google Scholar 

  27. Petterson H, Fitz CR, Harwood-Nash DCF, Armstrong E, Chuang SH (1982) Adverse reactions to myelography with metrizamide in infants, children and adolescents. Acta Radiol Diagn 23: 323–329

    Google Scholar 

  28. Baker RA, Hillman BJ, Strand RD, Kaufman SM (1978) Sequelae of metrizamide myelography in 200 examinations. AJR 130: 499–502

    Google Scholar 

  29. Kunkle EC, Ray BS, Wolff HG (1943) Experimental studies on headache. Analysis of the headache associated with changes in intracranial pressure. Arch Neurol Psychiatry 49: 323–358

    Google Scholar 

  30. Smith SE, Smith SA (1981) Heart rate variability in healthy subjects measured with a computer-based technique. Clin Sci 61: 379–383

    Google Scholar 

  31. Chapman WP, Jones CM (1944) Variations in cutaneous and visceral pain sensitivity in normal subjects. J Clin Invest 23: 81–91

    Google Scholar 

  32. Pedersen ON (1989) Poliklinisk radikulografi (lumbal myelografi) med ioheksol. Tidskr Nor Laegeforen 109: 947–950

    Google Scholar 

  33. Engel GL (1959) “Psychogenic” pain and the pain-prone patient. Am J Med 26: 899–918

    Google Scholar 

  34. Pilling LF, Brannick TL, Swenson WM (1967) Psychologic characteristics of psychiatric patients having pain as presenting symptom. Can Med Assoc J 97: 387–394

    Google Scholar 

  35. Redlich F, Moore BE, Kimbell I (1946) Lumbar puncture reactions: Relative importance of physiological and psychological factors. Psychosom Med 8: 386–398

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sand, T., Myhr, G., Stovner, L.J. et al. Side effects after lumbar iohexol myelography. Neuroradiology 31, 523–528 (1990). https://doi.org/10.1007/BF00340134

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00340134

Key words

Navigation