Summary
Side effects of iohexol lumbar myelography have been analyzed with respect to the influence of the type of radiological abnormality, sex and age in a group of 200 patients. Headache, postural headache, nausea and back/leg pain were significantly more frequent in patients without definite radiological abnormalities. Postural headache, nausea, dizziness and mental symptoms were more frequent in women, while headache, postural headache, nausea, dizziness, minor mental symptoms (i. e. anxiety or depression) and pain became less frequent with age. This pattern is similar to that reported after lumbar puncture. Young women without definite clinical signs of nerve root lesions probably have the greatest risk of experiencing side effects after iohexol lumbar myelography.
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Skalpe IO, Torbergsen T, Amundsen P, Presthus J (1973) Lumbar myelography with metrizamide. Acta Radiol [Suppl] 335: 367–379
Skalpe IO, Amundsen P (1975) Lumbar radiculography with metrizamide. Radiology 115: 91–95
Skalpe IO, Amundsen P (1975) Thoracic and cervical myelography with metrizamide. Radiology 116: 101–106
Hindmarsh T (1975) Lumbar myelography with meglumine iocarmate and metrizamide. Acta Radiol [Diagn] 16: 209–222
Ahlgren P (1975) Amipaque myelography. The side effects compared with Dimer X. Neuroradiology 9: 197–202
Rolfe EB, Maguire PD (1980) The incidence of headache following various techniques of metrizamide myelography. Br J Radiol 53: 840–844
Postacchini F, Massobrio M (1985) Outpatient lumbar myelography. Spine 10: 567–570
Nakstad P, Helgetveit A, Aaserud O, Ganes T, Nyberg-Hansen R (1984) Iohexol compared to metrizamide in cervical and thoracic myelography. Neuroradiology 26: 479–484
Lesak F (1986) Comparison of the side-effects of iohexol and metrizamide in lumbar myelography/radiculography. Ugeskr Laeger 148: 1206–1208
Shaw DD, Bach-Gansmo T, Dahlstrom K (1985) Iohexol: summary of North American and European clinical trials in adult lumbar, thoracic and cervical myelography with a new nonionic contrast medium. Invest Radiol [Suppl 1] 20: s44-s50
Skalpe IO, Nakstad P (1988) Myelography with iohexol (Omnipaque); A clinical report with special reference to the adverse effects. Neuroradiology 30: 169–174
Yu YL, du Boulay GH, Paul E (1986) Influence of certain factors on the manifestations of the adverse effects of metrizamide myelography. Neuroradiology 28: 339–343
Sand T, Stovner LJ, Dale L, Salvesen R (1987) Side effects after diagnostic lumbar puncture and lumbar iohexol myelography. Neuroradiology 29: 385–388
Dana CL (1917) Puncture headache JAMA 68: 1017
Tourtelotte WW, Haerer AF, Heller GL, Somers JE (1964) Post-lumbar puncture headaches. Thomas, Springfield, Illinois
Tourtelotte WW, Henderson WG, Tucker RP, Gilland O, Walker JE, Kokman E (1972) A randomized double-blind clinical trial comparing the 22 vs 26 G needle in the production of the post-lumbar puncture syndrome in normal individuals. Headache 12: 73–78
Nestvold K (1978) The influence of lumbar puncture needle size on postpuncture complications. Tidskr Nor Laegeforen 98: 569–570
Lange HU (1978) Angst und Neurotismus in der Genese von postpunktionellen Kopfschmerzen. Nervenarzt 49: 47–49
Hilton-Jones D, Harrad RA, Gill MW, Warlow CP (1982) failure of postural manoeuvres to prevent lumbar puncture headache. J Neurol Neurosurg Psychiatry 45: 743–746
Vilming ST, Schrader H, Monstad I (1988) Post-lumbar-puncture headache: The significance of body posture. Cephalalgia 8: 75–78
Vilming ST, Schrader H, Monstad I (1989) The significance of age, sex and initial cerebrospinal fluid pressure in postlumbar-puncture headache. Cephalalgia (in press)
Herkowitz HN, Romeyn R, Rothman RH (1983) The indications for metrizamide myelography. J Bone Joint Surg 65-A: 1144–1149
Simon JH, Ekholm SE, Kido DK, Utz R, Erickson J (1987) High-dose iohexol myelography. Radiology 163: 455–458
Sand T, Myhr G, Stovner LJ, Dale LG, Tangerud Å (1989) Side effects after ambulatory lumbar iohexol myelography. Neuroradiology 31: 49–54
Armitage P (1971) Statistical methods in medical research. Blackwell, Oxford London Edinburgh Melbourne, pp 129–131
Sand T (1989) Which factors affect reported headache incidences after lumbar myelography? Neuroradiology 31: 55–59
Petterson H, Fitz CR, Harwood-Nash DCF, Armstrong E, Chuang SH (1982) Adverse reactions to myelography with metrizamide in infants, children and adolescents. Acta Radiol Diagn 23: 323–329
Baker RA, Hillman BJ, Strand RD, Kaufman SM (1978) Sequelae of metrizamide myelography in 200 examinations. AJR 130: 499–502
Kunkle EC, Ray BS, Wolff HG (1943) Experimental studies on headache. Analysis of the headache associated with changes in intracranial pressure. Arch Neurol Psychiatry 49: 323–358
Smith SE, Smith SA (1981) Heart rate variability in healthy subjects measured with a computer-based technique. Clin Sci 61: 379–383
Chapman WP, Jones CM (1944) Variations in cutaneous and visceral pain sensitivity in normal subjects. J Clin Invest 23: 81–91
Pedersen ON (1989) Poliklinisk radikulografi (lumbal myelografi) med ioheksol. Tidskr Nor Laegeforen 109: 947–950
Engel GL (1959) “Psychogenic” pain and the pain-prone patient. Am J Med 26: 899–918
Pilling LF, Brannick TL, Swenson WM (1967) Psychologic characteristics of psychiatric patients having pain as presenting symptom. Can Med Assoc J 97: 387–394
Redlich F, Moore BE, Kimbell I (1946) Lumbar puncture reactions: Relative importance of physiological and psychological factors. Psychosom Med 8: 386–398
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Sand, T., Myhr, G., Stovner, L.J. et al. Side effects after lumbar iohexol myelography. Neuroradiology 31, 523–528 (1990). https://doi.org/10.1007/BF00340134
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DOI: https://doi.org/10.1007/BF00340134