Summary
The ability of collagenase to disaggregate a solid metastasizing lymphosarcoma has been shown to considerably increase with reducing environmental pH. It is suggested that this effect may be operating in vivo to release cells from a primary tumour.
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References
D. Glaves and L. Weiss, in: Cancer Invasion and Metastasis: Biological Mechanisms and Therapy, p. 175. Ed. S. B. Day, W. P. Laird Meyers, P. Stansly, S. Garattini and M. G. Lewis. Raven Press, New York 1977.
P. M. Gullino, F. H. Grantham, S. H. Smith and A. C. Haggerty, J. nat. Cancer Inst.34, 857 (1965).
L. Strauch, in: Tissue Interactions in Carcinogenesis, p. 399. Ed. D. Tarin, Academic Press, London 1972.
R. L. Carter, Am. J. Path.49, 637 (1966).
D. Guy, A. L. Latner and G. A. Turner, Br. J. Cancer36, 166 (1977).
T. Kono, Biochemistry7, 1106 (1968).
A. J. Barret, in: Lysosomes — A Laboratory Handbook, p. 46. Ed. J. T. Dingle. North Holland, Amsterdam 1972.
B. Sylvén, in: Chemotherapy of Cancer Dissemination and Metastasis, p. 129. Ed. S. Garattini and G. Franchi. Raven Press, New York 1973.
J. F. Woessner, Jr, in: Proteolysis and Physiological Regulation, Miami Winter Symposia, p. 357. Ed. D. W. Ribbons and K. Brew. Academic Press, New York 1976.
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Turner, G.A. Increased release of tumour cells by collagenase at acid pH: A possible mechanism for metastasis. Experientia 35, 1657–1658 (1979). https://doi.org/10.1007/BF01953252
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DOI: https://doi.org/10.1007/BF01953252