Skip to main content
SpringerLink
Log in

Diffusion-Weighted Imaging and ADC Mapping of Head-and-Neck Paragangliomas

Initial Experience*

Diffusionsbildgebung und ADC-Mapping von Glomustumoren: Erste Erfahrungen

  • Original Article
  • Published:
Clinical Neuroradiology Aims and scope Submit manuscript

Abstract

Background:

Paragangliomas are rare, hypervascularized benign tumors. In some cases a clear differentiation of paragangliomas and other entities is impossible.

Patients and Methods:

The authors evaluated ten patients with skull base lesions (paraganglioma n = 7, meningioma n = 1, giant cell tumor n = 1, and neurinoma n = 1) in addition to conventional magnetic resonance imaging (MRI) with diffusion-weighted imaging (DWI), and calculation of apparent diffusion coefficient (ADC).

Results:

Mean ADC values ± standard deviation of the paragangliomas were 1.304 ± 0.257 × 10–3 mm2/s and differed from ADC values of the other jugular fossa tumors with 0.743 ± 0.108 × 10–3 mm2/s and measurement derived from the cerebellum with 0.802 ± 0.075 × 10–3 mm2/s.

Conclusion:

Due to the difference of ADC values, the authors propose that DWI and ADC mapping could be a promising tool in the diagnostic work-up of paragangliomas.

Zusammenfassung

Hintergrund:

Paragangliome sind seltene benigne Tumoren. In wenigen Fällen ist jedoch eine Abgrenzung zu wichtigen Differentialdiagnosen nicht möglich.

Patienten und Methodik:

In die vorliegende Studie wurden zehn Patienten mit Raumforderungen der Schädelbasis eingeschlossen; sieben Glomus-jugulare-Tumoren, ein Meningeom, ein Neurinom und ein Riesenzelltumor. Zusätzlich zur konventionellen MR-Bildgebung wurden eine Diffusionsbildgebung (DWI) und ein apparentes Diffusionskoeffizienten- (ADC-)Mapping durchgeführt.

Ergebnisse:

Die mittleren ADC-Werte ± Standardabweichung lagen für die Glomustumoren bei 1,304 ± 0,257 × 10–3mm2/s, für die Vergleichsgruppe bei 0,743 ± 0,108 × 10–3 mm2/s und 0,802 ± 0,075 × 10–3 mm2/s für das angrenzende Kleinhirn.

Schlussfolgerung:

Aufgrund der deutlichen Unterschiede der ADC-Werte scheinen die DWI und das ADC-Mapping in der Diagnostik von Glomustumoren einen wertvollen Beitrag leisten zu können.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Neumann HP, Pawlu C, Peczkowska M, Bausch B, McWhinney SR, Muresan M, Buchta M, Franke G, Klisch J, Bley TA, Hoegerle S, Boedeker CC, Opocher G, Schipper J, Januszewicz A, Eng C, European-American Paraganglioma Study Group. Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations. JAMA 2004;292:943–51

    Article  PubMed  CAS  Google Scholar 

  2. Löwenheim H, Koerbel A, Ebner FH, Kumagami H, Ernemann U, Tatagiba M. Differentiating imaging findings in primary and secondary tumors of the jugular foramen. Neurosurg Rev 2006;29:1–11, discussion 12–3

    Article  PubMed  Google Scholar 

  3. Arnold SM, Strecker R, Scheffler K, Spreer J, Schipper J, Neumann HPH, Klisch J. Dynamic contrast enhancement of paragangliomas of the head and neck: evaluation with time-resolved 2D-MR projection angiography. Eur Radiol 2003;13:1608–11

    Article  PubMed  Google Scholar 

  4. Coley SC, Romanowski CAJ, Hodgson TJ, Griffith PD. Dural arteriovenous fistulae: non-invasive diagnosis with dynamic MR digital subtraction angiography. AJNR Am J Neuroradiol 2002;23:404–7

    PubMed  Google Scholar 

  5. Klisch J, Strecker R, Hennig J, Schumacher M. Time resolved projection MRA: clinical application in intracranial vascular malformation. Neuroradiology 2000;42:104–7

    Article  PubMed  CAS  Google Scholar 

  6. Ziyeh S, Schumacher M, Strecker R, Rossler J, Hochmuth A, Klisch J. Head and neck vacular malformations: time-resolved MR projection angiography. Neuroradiology 2003;45:681–6

    Article  PubMed  CAS  Google Scholar 

  7. Strecker R, Scheffler K, Klisch J, Lenhardt S, Winterer J, Laubenberger J, Fischer H, Hennig J. Fast functional MRA using time-resolved projection MR angiography with correlation analysis. Magn Reson Med 2000;43:303–9

    Article  PubMed  CAS  Google Scholar 

  8. Wetzel SG, Bilecen D, Lyrer P. Cerebral dural arteriovenous fistulas: detection by dynamic MRPA. AJR Am J Roentgenol 2000;174:1293–5

    PubMed  CAS  Google Scholar 

  9. Yoshikawa T, Aoki S, Hori M, Nambu A, Kumagai H, Araki T. Time-resolved two-dimensional thick-slice magnetic resonance digital subtraction angiography. Eur Radiol 2000;10:736–44

    Article  PubMed  CAS  Google Scholar 

  10. Barger AV, Block WF, Toropov Y, Grist TM, Mistretta CA. Time-resolved contrast-enhanced imaging with isotropic resolution and broad coverage using an undersampled 3D projection trajectory. Magn Reson Med 2002;48:297–305

    Article  PubMed  Google Scholar 

  11. Vogl TJ, Mack MG, Juergens M, Bergman C, Grevers G, Jacobsen TF, Lissner J, Felix R. Skull base tumors: gadodiamide injection-enhanced MR-imaging: dropout effect in the early enhancement pattern of paragangliomas versus different tumors. Radiology 1993;188:339–48

    PubMed  CAS  Google Scholar 

  12. Fisch U, Mattox D. Microsurgery of the skull base. Stuttgart–New York: Thieme, 1988:149–53

  13. Sumi M, Sakihama N, Sumi T, Morikawa M, Uetani M, Kabasawa H, Shigeno K, Hayashi K, Takahashi H, Nakamura T. Discrimination of metastatic cervical lymph nodes with diffusion-weighted MR imaging in patients with head and neck cancer. AJNR Am J Neuroradiol 2003; 24:1627–34

    PubMed  Google Scholar 

  14. Habermann CR, Gossrau P, Graessner J, Arndt C, Cramer MC, Reitmeier F, Jaehne M, Adam G. Diffusion-weighted echo-planar MRI: a valuable tool for differentiating primary parotid tumors? Rofo 2005;177:940–5

    PubMed  CAS  Google Scholar 

  15. Abdel Razek AA, Soliman NY, Elkhamary S, Alsharaway MK, Tawfik A. Role of diffusion-weighted MR imaging in cervical lymphadenopathy. Eur Radiol 2006;16:1468–77

    Article  PubMed  Google Scholar 

  16. Aschenbach R, Eger C, Esser D, Klisch J, Basche S. Diffusion-weighted imaging and ADC-mapping of paragangliomas of the jugular fossa at 1.5T. Proceedings of the 43rd Annual Meeting of ASNR 2005, Toronto, May 23, 2005:52.presentation 104

  17. Tzika AA, Zarifi MK, Goumnerova L, Astrakas LG, Zurakowski D, Young- Poussaint T, Anthony DC, Scott RM, Black PM. Neuroimaging in pediatric brain tumors: Gd-DTPA-enhanced, hemodynamic, and diffusion MR imaging compared with MR spectroscopic imaging. AJNR Am J Neuroradiol 2002;23:322–33

    PubMed  Google Scholar 

  18. Castillo M, Smith JK, Kwock L, Wilber K. Apparent diffusion coefficient in the evaluation of high-grade cerebral gliomas. AJNR Am J Neuroradiol 2001;22:60–4

    PubMed  CAS  Google Scholar 

  19. Sinha S, Bastin ME, Whittle IR, Wardlaw JM. Diffusion tensor imaging of high-grade cerebral gliomas. AJNR Am J Neuroradiol 2002;23:520–7

    PubMed  Google Scholar 

  20. Kono K, Inoue Y, Nakayama K, Shakudo M, Morino M, Ohata K, Wakasa K, Yamada R. The role of diffusion weighted imaging in patients with brain tumors. AJNR Am J Neuroradiol 2001;22:1081–8

    PubMed  CAS  Google Scholar 

  21. DeLano MC, Cooper TG, Siebert JE, Potchen MJ, Kuppusamy K. High b-value diffusion weighted MR imaging of adult brain: image contrast and apperent diffusion coefficient map features. AJNR Am J Neuroradiol 2000;21:1830–6

    PubMed  CAS  Google Scholar 

  22. Mack MG, Rieger J, Baghi M, Bisdas S, Vogl TJ. Cervical lymph nodes. Eur J Radiol 2008;66:493–500

    Article  PubMed  Google Scholar 

  23. Chen S, Ikawa F, Kurisu K, Arita K, Takaba J, Kanou Y. Quantitative MR evaluation of intracranial epidermoid tumors by fast fluid-attenuated inversion recovery imaging and echo-planar diffusion-weighted imaging. AJNR Am J Neuroradiol 2001;22:1089–96

    PubMed  CAS  Google Scholar 

  24. Wang J, Takashima S, Takayama F, Kawakami S, Saito A, Matsushita T, Momose M, Ishiyama T. Head and neck lesions: characterization with diffusion- weighted echo-planar MR imaging. Radiology 2001;220:621–30

    Article  PubMed  CAS  Google Scholar 

  25. Simon JE, Czechowsky DK, Hill MD, Harris AD, Buchan AM, Frayne R. Fluid-attenuated inversion recovery preparation: not an improvement over conventional diffusion-weighted imaging at 3T in acute ischemic stroke. AJNR Am J Neuroradiol 2004;25:1653–8

    PubMed  Google Scholar 

  26. Ziyeh S, Strecker R, Berlis A, Weber J, Klisch J, Mader I. Dynamic 3D MR angiography of intra and extra cranial vascular malformations at 3T. A technical note. AJNR Am J Neuroradiol 2005;26:630–4

    PubMed  CAS  Google Scholar 

  27. Srinivasan A, Dvorak R, Perni K, Rohrer S, Mukherji SK. Differentiation of benign and malignant pathology in the head and neck using 3T apparent diffusion coefficient values: early experience. AJNR Am J Neuroradiol 2008;29:40–4

    Article  PubMed  CAS  Google Scholar 

  28. Nakayama T, Yoshimitsu K, Irie H, Aibe H, Tajima T, Shinozaki K, Nishie A, Asayama Y, Kakihara D, Matsuura S, Honda H. Usefulnes of the calculated apparent diffusion coefficient value in the differential diagnosis of retroperitoneal masses. J Magn Reson Imaging 2004;20:735–42

    Article  PubMed  Google Scholar 

  29. Vandecaveye V, De Keyzer F, Nuyts S, Deraedt K, Dirix P, Hamaekers P, Vander Poorten V, Delaere P, Hermans R. Detection of head and neck squamous cell carcinoma with diffusion weighted MRI after (chemo)therapy: correlation between radiologic and histopathologic findings. Int J Radiat Oncol Biol Phys 2007;67:960–71

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Diagnostic and Interventional Radiology and Neuroradiology, HELIOS Klinikum Erfurt GmbH, Erfurt, Germany

    René Aschenbach MD, Steffen Basche & Joachim Klisch

  2. Department of Diagnostic and Interventional Radiology, Center of Radiology, University Hospital Frankfurt/Main, Frankfurt/Main, Germany

    Thomas Josef Vogl

  3. Department of Diagnostic and Interventional Radiology and Neuroradiology, HELIOS Klinikum Erfurt GmbH, Nordhäuser Straße 74, 99089, Erfurt, Germany

    René Aschenbach MD

Authors
  1. René Aschenbach MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Steffen Basche
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Thomas Josef Vogl
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Joachim Klisch
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to René Aschenbach MD.

Additional information

*Published in part at the 43rd Annual Meeting of the American Society of Neuroradiology, May 23, 2005, Toronto, Canada.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Aschenbach, R., Basche, S., Vogl, T.J. et al. Diffusion-Weighted Imaging and ADC Mapping of Head-and-Neck Paragangliomas. Clin Neuroradiol 19, 215–219 (2009). https://doi.org/10.1007/s00062-009-9004-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00062-009-9004-1

Key Words

Schlüsselwörter

Search

Navigation