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Single Center Experience in Stent-Assisted Coiling of Complex Intracranial Aneurysms Using Low-Profile Stents

The ACCLINO® Stent Versus the ACCLINO® Flex Stent

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Abstract

Purpose

The introduction of low-profile stent systems has broadened and facilitated the treatment of complex intracranial aneurysms. This retrospective case series study was conducted to assess and compare the clinical and angiographic outcomes of patients with complex intracranial aneurysms who were treated with ACCLINO® (AS) and ACCLINO® flex stents (AFS).

Methods

In 85 patients (female 61; male 24) a total of 95 complex intracranial aneurysms, 71 (74.7%) in the anterior circulation and 24 (25.3%) in the posterior circulation were treated. Angiographic and clinical data, aneurysm characteristics and follow-up results were analyzed.

Results

The AS was used in 47 cases (49.5%) and the AFS in 48 cases (50.5%). Initial angiography after the intervention showed a complete occlusion in 52.6% (Raymond-Roy occlusion classification [RROC] 1), a neck remnant in 38.9% (RROC 2) and an incomplete occlusion in 8.4% (RROC 3). Follow-up (AS: 25.2 ± 15.4 months; AFS: 9.6 ± 8.0 months) revealed an occlusion rate of 70.5% (RROC 1), 27.4% (RROC 2) and 2.1% (RROC 3). There was no statistically significant difference between the initial (p = 0.484) and the follow-up occlusion rate (p = 0.284) when comparing the two devices. Recoiling was performed in 8 cases (8.4%). The overall complication rate was 9.5% with 5 strokes (5.3%), 2 hemorrhages (2.1%), 1 in-stent stenosis (1.1%), 1 stent occlusion (1.1%) and 2 stent thromboses (2.1%). There was no procedure-related mortality.

Conclusion

Using the ACCLINO® and ACCLINO® flex stent system is a feasible and effective procedure with an acceptable safety profile. Initial and follow-up angiographic results were satisfactory.

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Abbreviations

AFS:

ACCLINO® flex stent

AS:

ACCLINO® stent

LVIS:

Low-profile visualized intraluminal support

MCA:

Middle cerebral artery

MRI:

Magnetic resonance imaging

PICA:

Posterior inferior cerebellar artery

RROC:

Raymond-Roy occlusion classification

SAH:

Subarachnoid hemorrhage

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Funding

This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Neuroradiology, Universitätsklinikum des Saarlandes, Medizinische Fakultät, Universität des Saarlandes, Kirrbergerstraße, 66421, Homburg/Saar, Germany

    Philipp Dietrich, Alica Gravius, Ruben Mühl-Benninghaus, Umut Yilmaz, Michael Kettner, Wolfgang Reith & Andreas Simgen

  2. Department of Anaesthesiology, Universitätsklinikum des Saarlandes und Medizinische Fakultät, Universität des Saarlandes, Homburg/Saar, Germany

    Hagen Bomberg

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  1. Philipp Dietrich
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  2. Alica Gravius
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  3. Ruben Mühl-Benninghaus
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  5. Michael Kettner
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  6. Hagen Bomberg
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  7. Wolfgang Reith
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  8. Andreas Simgen
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Correspondence to Philipp Dietrich.

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Conflict of interest

P. Dietrich, A. Gravius, R. Mühl-Benninghaus, U. Yilmaz, M. Kettner, H. Bomberg, W. Reith and A. Simgen declare that they have no competing interests.

Ethical standards

All procedures performed in studies involving human participants or on human tissue were in accordance with the ethical standards of the institutional and/or national research committee and with the 1975 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study. Additional written informed consent was obtained from all individual participants or their legal representatives for whom identifying information is included in this article. Ethics committee approval was obtained (identification number 203/18).

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Dietrich, P., Gravius, A., Mühl-Benninghaus, R. et al. Single Center Experience in Stent-Assisted Coiling of Complex Intracranial Aneurysms Using Low-Profile Stents. Clin Neuroradiol 31, 99–106 (2021). https://doi.org/10.1007/s00062-020-00883-5

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