Abstract
Although Guglielmi detachable coil (GDC) systems have been generally accepted for treatment of intracranial aneurysms, primary stenting of aneurysms using porous stents or implantation of coils after stent placement remains experimental. Testing of these new methods requires an animal model which imitates human aneurysms in size, configuration and neck morphology. We assessed in detail the technical requirements of and steps for transfemoral stent treatment of experimentally induced aneurysms at the top of the brachiocephalic trunk in rabbits. We created aneurysms in ten rabbits by distal ligation and intraluminal digestion of the right common carotid artery with elastase. We treated five animals with porous stents alone, and five with stents plus coiling via the meshes of the stent, which permitted dense packing of coils. No complications related to the procedures occurred. In all animals, even in those treated solely with porous stents, total occlusion of the aneurysm was achieved. Our animal model can be suitable for testing the biocompatibility and occlusion rate of new methods and devices for the treatment of experimental aneurysms.
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Acknowledgements
We greatly appreciate the help of Dr S. Kinzel concerning animal anaesthesia and of Professor W. Küpper, Dr H. Kommans, Dr C. Herweg, T. Stopinski and I. Hermanns concerning animal care. Without their dedication this work would not have been possible. This work was funded by the Stiftung Tumorforschung Kopf Hals, by the Deutsche Forschungsgemeinschaft (KR 2008/4-1), and by the Else Kröner-Fresenius-Stiftung.
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Hans, F.J., Krings, T., Möller-Hartmann, W. et al. Endovascular treatment of experimentally induced aneurysms in rabbits using stents: a feasibility study. Neuroradiology 45, 430–434 (2003). https://doi.org/10.1007/s00234-003-1008-y
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DOI: https://doi.org/10.1007/s00234-003-1008-y