Abstract
Introduction
The discussion on the use of protection devices (PDs) in carotid artery stenting (CAS) is gaining an increasing role in lowering the periprocedural complication rates. While many reviews and reports with retrospective data analysis do promote the use of PDs the most recent multi-centre trials are showing advantages for unprotected CAS combined with closed-cell stent designs.
Methods
We retrospectively analysed 358 unprotected CAS procedures performed from January 2003 to June 2009 in our clinic. Male/female ratio was 2.68/1. The average age was 69.3 years. Seventy-three percent (261/358) showed initial neurological symptoms. All patients were treated on a standardised interventional protocol. A closed and small-sized cell designed stent was implanted in most cases (85.2%). One hundred seventy-one (47.8%) were controlled by Doppler ultrasonography usually at first in a 3-month and later in 6-month intervals.
Results
The peri-interventional and 30-day mortality/stroke rate was 4.19% (15/358). These events included three deaths, five hyperperfusion syndromes (comprising one death by a secondary fatal intracranial haemorrhage), one subarachnoid haemorrhage and seven ischaemic strokes. Only 20% (3/15) of all complications occurred directly peri-interventional. The overall peri-interventional complication rate was 0.8% (3/358). Most complications occurred in initial symptomatic patients (5.36%). The in-stent restenosis rate for more than 70% was 7% (12/171) detected at an average of 9.8 month.
Conclusion
Our clinical outcome demonstrates that unprotected CAS with small cell designed stents results in a very low procedural complication rate, which makes the use of a protection device dispensable.
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References
Kerber CW, Hornwell LD, Loehnden OL (1980) Catheter dilatation of proximal carotid stenosis during distal bifurcation endarterectomy. AJNR 1:348–349
Bockenheimer SAM, Mathias K (1983) Percutaneous transluminal angioplasty of atherosclerotic internal carotid artery stenosis. AJNR 4:791–792
Wiggli U, Grazl O (1983) Transluminal angioplasty of stenotic carotid arteries. Case reports and protocol. AJNR 4:793–795
Tievsky AL, Dury EM, Mardiat JG (1983) Transluminal angioplasty in postsurgical stenosis of the extracranial carotid artery. AJNR 4:800–802
Hasso AN, Bird CR (1983) Percutaneous transluminal angioplasty of carotid and vertebral arteries. In: Jang GD (ed) Angioplasty. New York, McGraw-Hill Book Company, pp 104–115
Diethrich EB, Gordon MH, Lopez-Galarza LA et al (1995) Intraluminal Palmaz stent implantation for treatment of recurrent carotid artery occlusive diseasa: a plan for the future. J Intervent Cardiol 8:213–218
Ringleb PA, Allenberg J, Bruckmann H, Eckstein HH, Fraedrich G, Hartmann M, Hennerici M, Jansen O, Klein G, Kunze A, Marx P, Niederkorn K, Schmiedt W, Solymosi L, Stingele R, Zeumer H, Hacke W (2006) 30 day results from the SPACE trial of stent-protected angioplasty versus carotid endarterectomy in symptomatic patients: a randomised non-inferiority trial. Lancet 368:1239–1247
Mas J-L, Chattellier G, Beyssen B et al (2006) Endarterectomy versus stenting in patients with symptomatic severe carotid stenosis. N Engl J Med 355:1660–1671
Coward LJ, McCabe DJ, Ederle J, Featherstone RL, Clifton A, Brown MM, CAVATAS Investigators (2007) Long-term outcome after angioplasty and stenting for symptomatic vertebral artery stenosis compared with medical treatment in the Carotid And Vertebral Artery Transluminal Angioplasty Study (CAVATAS): a randomized trial. Stroke 38(5):1526–1530
Hobson RW 2nd (2000) CREST (carotid revascularization endarterectomy versus stent trial): background, design, and current status. Semin Vasc Surg 13(2):139–143
Hobson RW 2nd, Howard VJ, Roubin GS, Brott TG, Ferguson RD, Popma JJ, Graham DL, Howard G, CREST Investigators (2004) Carotid artery stenting is associated with increased complications in octogenarians: 30-day stroke and death rates in the CREST lead-in phase. J Vasc Surg 40(6):1106–1111
Reimers B, Corvaja N, Moshiri S, Saccà S et al (2001) Cerebral protection with filter devices during carotid artery stenting. Circulation 104:12–15
Castriota F, Cremonesi A, Manetti R, Liso A, Oshoala K, Ricci E, Balestra G (2002) Impact of cerebral protection devices on early outcome of carotid stenting. J Endovasc Ther 9:786–792
Cremonesi A, Manetti R, Castriota F, Setacci F, Setacci C (2003) Protected carotid stenting: clinical advantages and complications of embolic protection devices in 442 consecutive patients. Stroke 34:1936–1943
Kastrup A, Groschel K, Krapf H, Brehm BR, Dichgans J, Schulz JB (2003) Early outcome of carotid angioplasty and stenting with and without cerebral protection devices: a systematic review of the literature. Stroke 34:813–819
Theiss W, Hermanek P, Mathias K et al (2008) Predictors of death and stroke after carotid angioplasty and stenting a subgroup analysis of the pro-CAS data. Stroke 39(8):2325–2330, Epub 2008 Jun 26
Garg N, Karagiorgos N, Pisimisis GT, Sohal DP, Longo GM, Johanning JM, Lynch TG, Pipinos II (2009) Cerebral protection devices reduce periprocedural strokes during carotid angioplasty and stenting: a systematic review of the current literature. J Endovasc Ther 16(4):412–427
Al-Mubarak N, Roubin GS, Vitek JJ, Iyer SS, New G, Leon MB (2001) Effect of the distal-balloon protection system on microembolization duringcarotid stenting. Circulation 104:1999–2002
Jaeger H, Mathias K, Drescher R, Hauth E, Bockisch G, Demirel E, Gissler HM (2001) Clinical results of cerebral protection with a filter device during stent implantation of the carotid artery. Cardiovasc Intervent Radiol 24:249–256
Al-Mubarak N, Colombo A, Gaines PA, Iyer SS, Corvaja N, Cleveland TJ, Macdonald S, Brennan C, Vitek JJ (2002) Multicenter evaluation of carotid artery stenting with a filter protection system. J Am Coll Cardiol 39:841–846
Guimaraens L, Sola MT, Matali A, Arbelaez A, Delgado M, Soler L, Balaguer E, Castellanos C, Ibanez J, Miquel L, Theron J (2002) Carotid angioplasty with cerebral protection and stenting: report of 164 patients (194 carotid percutaneous transluminal angioplasties). Cerebrovasc Dis 13:114–119
Jansen O, Fiehler J, Hartmann M, Brückmann H, for the SPACE investigators (2009) Protection or non-protection in carotid stent angioplasty—the influence of interventional techniques on outcome data from the SPACE Trial. Stroke 40:841–846
Duda Sh, Wiskirchen J, Tepe G, Bitzen M, Kaulich TW, Stoeckel D et al (2000) Physical properties of endovascular stents: an experimental comparison. J Vasc Interv Radiol 11:645–e654
Bosiers M, Deloose K, Verbist J, Peeters P (2005) Carotid artery stenting: which stent for which lesion? Vascular 13:205–e210
Orlandi G, Fanucchi S, Fioretti C, Acerbi G, Puglioli M, Padolecchia R, Sartucci F, Murri L (2001) Characteristics of cerebral microembolism during carotid stenting and angioplasty alone. Arch Neurol 58:1410–1413
Eckert B, Zeumer H (2003) Carotid artery stenting with or without protection devices? Strong opinions, poor evidence! Stroke 34:1941–1943
Fiehler J, Jansen O, Berger J, Eckstein HH, Ringleb PA, Stingele R (2008) Differences in complication rates among the centres in the SPACE study. Neuroradiology 50(12):1049–1053, Epub 2008 Sep 23
Wholey MH, Jarmolowski CR, Wholey M, Eles GR (2003) Carotid artery stent placement-ready for prime time? J Vasc Interv Radiol 14(1):1–10
Wholey MH, Wholey M, Mathias K et al (2000) Global experience in cervical carotid artery stent placement. Catheter Cardiovasc Interv 50(2):160–167
Schillinger M, Gschwendtner M, Reimers B, Trenkler J, Stockx L, Mair J, Macdonald S, Karnel F, Huber K, Minar E (2008) Does carotid stent cell design matter? Stroke 39(3):905–909
Brantley HP, Kiessling JL, Milteer HB Jr, Mendelsohn FO (2009) Hyperperfusion syndrome following carotid artery stenting: the largest single-operator series to date. J Invasive Cardiol 21(1):27–30
Nederkoorn PJ, Brown MM (2009) Optimal cut-off criteria for duplex ultrasound for the diagnosis of restenosis in stented carotid arteries: review and protocol for a diagnostic study BMC. Neurology 9:36
Lal BK, Hobson RW 2nd, Tofighi B, Kapadia I, Cuadra S, Jamil Z (2008) Duplex ultrasound velocity criteria for the stented carotid artery. J Vasc Surg 47:63–73
Spies Ch, Doshi R, Spoon J, Snell RJ (2007) Carotid artery stent type influences duplex ultrasonography derived peak systolic velocity: findings of an in-vitro model. Catheter Cardiovasc Interv 70(2):309–315
Chaktoura EY et al (2001) In-stent restenosis after carotid angioplasty-stenting: incidence and management. J Vasc Surg 33:220–225
Willfort-Ehringer A et al (2002) Single-center experience with carotid stent restenosis. J Endovac Ther 9:299–307
Setacci C et al (2005) In-stent restenosis after carotid artery angioplasty and stenting: a challenge for the vascular surgeon. Eur J Vasc Endovasc Surg 29:601–607
Levy EI et al (2005) Frequency and management of recurrent stenosis after carotid artery stent implantation. J Neurosurg 102:29–37
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Tietke, M.W.K., Kerby, T., Alfke, K. et al. Complication rate in unprotected carotid artery stenting with closed-cell stents. Neuroradiology 52, 611–618 (2010). https://doi.org/10.1007/s00234-010-0672-y
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DOI: https://doi.org/10.1007/s00234-010-0672-y