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Transit time corrected arterial spin labeling technique aids to overcome delayed transit time effect

  • Diagnostic Neuroradiology
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Abstract

Purpose

This study aimed to evaluate the usefulness of transit time corrected cerebral blood flow (CBF) maps based on multi-phase arterial spin labeling MR perfusion imaging (ASL-MRP).

Methods

The Institutional Review Board of our hospital approved this retrospective study. Written informed consent was waived. Conventional and multi-phase ASL-MRPs and dynamic susceptibility contrast MR perfusion imaging (DSC-MRP) were acquired for 108 consecutive patients. Vascular territory-based volumes of interest were applied to CBF and time to peak (TTP) maps obtained from DSC-MRP and CBF maps obtained from conventional and multi-phase ASL-MRPs. The concordances between normalized CBF (nCBF) from DSC-MRP and nCBF from conventional and transition time corrected CBF maps from multi-phase ASL-MRP were evaluated using Bland-Altman analysis. In addition, the dependence of difference between nCBF (ΔnCBF) values obtained from DSC-MRP and conventional ASL-MRP (or multi-phase ASL-MRP) on TTP obtained from DSC-MRP was also analyzed using regression analysis.

Results

The values of nCBFs from conventional and multi-phase ASL-MRPs had lower values than nCBF based on DSC-MRP (mean differences, 0.08 and 0.07, respectively). The values of ΔnCBF were dependent on TTP values from conventional ASL-MRP technique (F = 5.5679, P = 0.0384). No dependency of ΔnCBF on TTP values from multi-phase ASL-MRP technique was revealed (F = 0.1433, P > 0.05).

Conclusion

The use of transit time corrected CBF maps based on multi-phase ASL-MRP technique can overcome the effect of delayed transit time on perfusion maps based on conventional ASL-MRP.

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Acknowledgements

The enhanced ASL-PWI sequence is a work-in-progress prototype (not commercially available) provided by GE.

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Authors and Affiliations

  1. Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea

    Tae Jin Yun, Chul-Ho Sohn, Roh-Eul Yoo, Kyung Mi Kang, Seung Hong Choi, Ji-hoon Kim & Sun-Won Park

  2. Department of Radiology, Seoul National University Hospital, 101, Daehangno, Jongno-gu, Seoul, 03080, Republic of Korea

    Tae Jin Yun, Chul-Ho Sohn, Roh-Eul Yoo, Kyung Mi Kang, Seung Hong Choi & Ji-hoon Kim

  3. Department of Radiology, Seoul National University Boramae Medical Center, Seoul, Republic of Korea

    Sun-Won Park

  4. GE Healthcare Korea, Seoul, Republic of Korea

    Moonjung Hwang

  5. GE Healthcare Canada, Calgary, Canada

    R. Marc Lebel

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  1. Tae Jin Yun
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Corresponding author

Correspondence to Chul-Ho Sohn.

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Funding

No funding was received for this study.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in the studies involving human participants were in accordance with the ethical standards of the Seoul National University Hospital Institutional Review Board and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. For this type of study formal consent is not required.

Informed consent

For this type of retrospective study formal consent is not required.

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Yun, T.J., Sohn, CH., Yoo, RE. et al. Transit time corrected arterial spin labeling technique aids to overcome delayed transit time effect. Neuroradiology 60, 255–265 (2018). https://doi.org/10.1007/s00234-017-1969-x

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  • DOI: https://doi.org/10.1007/s00234-017-1969-x

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