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Atypical MRI features of Wilson's disease: high signal in globus pallidus on T1-weighted images

  • DIAGNOSTIC NEURORADIOLOGY
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Abstract

Most reports of MRI in Wilson's disease have been of abnormal low-signal lesions on T1-weighted images and high signal intensity on T2-weighted images. In contrast, we report three patients who had high-signal lesions in the globus pallidus on T1-weighted images, a finding seen in patients with portal-systemic encephalopathy. The possible causes include the paramagnetic effect of copper or iron and accumulation of Alzheimer type II glial cells.

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Authors and Affiliations

  1. Third Department of Internal Medicine, National Defense Medical College, 3-2, Namiki, Tokorozawa, Saitama, Japan, , , , , , JP

    H. Mochizuki, K. Kamakura, T. Masaki, M. Okano & N. Nagata

  2. Department of Pediatrics, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, Japan, , , , , , JP

    A. Inui & T. Fujisawa

  3. Department of Radiology, National Defense Medical College, 3-2, Namiki, Tokorozawa, Saitama, Japan, , , , , , JP

    T. Kaji

Authors
  1. H. Mochizuki
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  2. K. Kamakura
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  3. T. Masaki
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  4. M. Okano
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  5. N. Nagata
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  6. A. Inui
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  7. T. Fujisawa
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  8. T. Kaji
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Received: 26 January 1996 Accepted: 1 April 1996

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Mochizuki, H., Kamakura, K., Masaki, T. et al. Atypical MRI features of Wilson's disease: high signal in globus pallidus on T1-weighted images. Neuroradiology 39, 171–174 (1997). https://doi.org/10.1007/s002340050386

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  • DOI: https://doi.org/10.1007/s002340050386

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