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Diffusion tensor imaging of normal brain development

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Abstract

Diffusion tensor imaging (DTI) is an MRI technique that can measure the macroscopic structural organization in brain tissues. DTI has been shown to provide information complementary to relaxation-based MRI about the changes in the brain’s microstructure. In the pediatric population, DTI enables quantitative observation of the maturation process of white matter structures. Its ability to delineate various brain structures during developmental stages makes it an effective tool with which to characterize both the normal and abnormal anatomy of the developing brain. This review will highlight the advantages, as well as the common technical pitfalls of pediatric DTI. In addition, image quantification strategies for various DTI-derived parameters and the normal brain developmental changes associated with these parameters are discussed.

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Acknowledgments

The authors thank Ms. Mary McAllister for help with manuscript editing. This publication was made possible by NIH grants RO1AG20012, and P41EB015909 from NCRR/NIBIB (SM), R01HD065955 from NICHD (KO) and R03EB014357 from NIBIB/NIH (AF). Its contents are solely the responsibility of the authors and do not necessarily represent the official view of any of these institutes.

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Authors and Affiliations

  1. The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 210 Traylor Building, 720 Rutland Ave., Baltimore, MD, 21205, USA

    Shoko Yoshida

  2. The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 217 Traylor Building, 720 Rutland Ave., Baltimore, MD, 21205, USA

    Kenichi Oishi & Andreia V. Faria

  3. The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 330 Traylor Building, 720 Rutland Ave., Baltimore, MD, 21205, USA

    Susumu Mori

  4. F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA

    Susumu Mori

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  1. Shoko Yoshida
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  2. Kenichi Oishi
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  3. Andreia V. Faria
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  4. Susumu Mori
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Correspondence to Susumu Mori.

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Yoshida, S., Oishi, K., Faria, A.V. et al. Diffusion tensor imaging of normal brain development. Pediatr Radiol 43, 15–27 (2013). https://doi.org/10.1007/s00247-012-2496-x

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  • DOI: https://doi.org/10.1007/s00247-012-2496-x

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