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A review of the literature for intra-arterial chemotherapy used to treat retinoblastoma

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Abstract

Retinoblastoma is a malignancy of the retina that usually presents before the age of 5 years. Sporadic retinoblastoma is most often unilateral and with no hereditary influence, whereas familial retinoblastoma presents unilaterally or bilaterally in conjunction with genetic inheritance. Several treatments have been attempted with the goals of saving the child’s life, salvaging the eye, and preserving vision. Alternative methods including external beam radiation, systemic chemotherapy and focal therapies have been shown to be effective but carry a risk of enucleation and other complications proportional to the severity of the tumor. Selective intra-arterial chemotherapy for retinoblastoma began in 1988 in Japan and has emerged in the last 7 years in the United States as a feasible, effective and minimally invasive treatment option. We review the retinoblastoma treatment literature focusing on intra-arterial chemotherapy.

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Acknowledgments

The authors extend our gratitude to Lydia Gregg, assistant professor and medical illustrator at the Johns Hopkins School of Medicine, for preparing the illustrations.

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Authors and Affiliations

  1. Division of Interventional Neuroradiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Emily Wyse & Monica S. Pearl

  2. Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    James T. Handa

  3. Division of Pediatric Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Alan D. Friedman

  4. Interventional Neuroradiology, Children’s National Medical Center, Washington, DC, USA

    Monica S. Pearl

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  1. Emily Wyse
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  2. James T. Handa
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  4. Monica S. Pearl
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Correspondence to Monica S. Pearl.

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Wyse, E., Handa, J.T., Friedman, A.D. et al. A review of the literature for intra-arterial chemotherapy used to treat retinoblastoma. Pediatr Radiol 46, 1223–1233 (2016). https://doi.org/10.1007/s00247-016-3554-6

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  • DOI: https://doi.org/10.1007/s00247-016-3554-6

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