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Clinical impact of the callosal angle in the diagnosis of idiopathic normal pressure hydrocephalus

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Abstract

The utility of measuring the corpus callosal angle (CA) for the diagnosis of idiopathic normal pressure hydrocephalus (INPH) was investigated. Three-dimensional magnetic resonance imaging (MRI) was performed in 34 INPH patients, 34 Alzheimer’s disease (AD) patients, and 34 normal control (NC) subjects. Measurement of the CA on the coronal MR images of the posterior commissure perpendicular to the anteroposterior commissure plane was performed for all subjects. The CA of the INPH group (mean ± SD, 66 ± 14°) was significantly smaller than those of the AD (104 ± 15°) and NC (112 ± 11°) groups. When using the threshold of the mean − 2SD value of the NC group (= 90°), an accuracy of 93%, sensitivity of 97%, and specificity of 88% were observed for discrimination of INPH from AD patients. Measuring the CA helps in differentiating INPH patients from AD and normally aged subjects.

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Authors and Affiliations

  1. Department of Radiology and Nuclear Medicine, Hyogo Brain and Heart Center, 520 Saisho-Ko, Himeji, Hyogo, 670–0981, Japan

    Kazunari Ishii, Tomonori Kanda, Aya Harada, Naokazu Miyamoto, Takafumi Uemura & Toshiki Yoshikawa

  2. Department of Neurosurgery, Hyogo Brain and Heart Center, Himeji, Hyogo, Japan

    Tetsuro Kawaguchi

  3. Institute for Aging Brain and Cognitive Disorders, Hyogo Brain and Heart Center, Himeji, Hyogo, Japan

    Kenichi Shimada, Shingo Ohkawa & Etsuro Mori

  4. Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan

    Etsuro Mori

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  1. Kazunari Ishii
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  2. Tomonori Kanda
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  3. Aya Harada
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  4. Naokazu Miyamoto
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  5. Tetsuro Kawaguchi
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  6. Kenichi Shimada
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  7. Shingo Ohkawa
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  8. Takafumi Uemura
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  9. Toshiki Yoshikawa
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  10. Etsuro Mori
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Correspondence to Kazunari Ishii.

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Ishii, K., Kanda, T., Harada, A. et al. Clinical impact of the callosal angle in the diagnosis of idiopathic normal pressure hydrocephalus. Eur Radiol 18, 2678–2683 (2008). https://doi.org/10.1007/s00330-008-1044-4

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  • DOI: https://doi.org/10.1007/s00330-008-1044-4

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