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Combination of diffusion tensor imaging and conventional MRI correlates with isocitrate dehydrogenase 1/2 mutations but not 1p/19q genotyping in oligodendroglial tumours

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Abstract

Objectives

To explore the correlations of conventional MRI (cMRI) and diffusion tensor imaging (DTI) values with the 1p/19 codeletion and IDH mutations in oligodendroglial tumours (OTs).

Methods

Eighty-four patients with OTs who underwent cMRI and DTI were retrospectively reviewed. The maximal fractional anisotropy and minimal apparent diffusion coefficient (ADC) were measured and compared using the Mann-Whitney U test. Receiver operating characteristic curves, logistic regression analysis and four-table statistics analysis were performed to predict genotypings.

Results

OTs with 1p/19q codeletion or IDH mutations were prone to locate in frontal (P = 0.106 and 0.005, respectively) and insular lobes and were associated with absent or blurry contrast enhancement (P = 0.040 and 0.013, respectively). DTI values showed significant differences between OTs with and without IDH mutations (P < 0.05) but not in OTs with and without 1p/19q loss. The Ki-67 index significantly correlated with IDH mutations (P = 0.002) but not with 1p/19q codeletion. A combination of DTI and cMRI for the identification of IDH mutations resulted in sensitivity, specificity, positive and negative predictive values of 92.2 %, 75.8 %, 93.8 % and 71.1 %, respectively.

Conclusions

Combination of DTI and cMRI correlates with isocitrate dehydrogenase 1/2 mutations but not 1p/19q genotyping in OTs.

Key Points

• OTs with 1p/19q codeletion were associated with absent or blurry contrast enhancement

• OTs with IDH mutations were also associated with absent or blurry contrast enhancement

• OTs with IDH mutations were prone to locate in frontal and insular lobes

• DTI values can provide a non-invasive method for assessing the IDH status of OTs

• A combination of DTI and cMRI correlates with isocitrate dehydrogenase 1/2 mutations

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Abbreviations

AUC:

Area under the curve

cMRI:

Conventional MRI

FA:

Fractional anisotropy

IDH:

Isocitrate dehydrogenase

OTs:

Oligodendroglial tumours

rmADC:

Ratio of minimal ADC

rmFA:

Ratio of maximal FA

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Acknowledgments

Ji Xiong and Wenli Tan contributed equally to this paper. The scientific guarantor of this publication is Daoying Geng. The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. This study has received funding from a grant from the National Nature Science Foundation of China (No. 81402051) to Ji Xiong, and the National Nature Science Foundation of China (No. 81471627), the Specialized Research Fund for the Doctoral Program of Higher Education of China (No. 20130071130011), and the Shanghai Health System Important Disease Joint Research Project (No. 2013ZYJB009) to Daoying Geng, and the National Nature Science Foundation of China (No. 81201071), the Science and Technical Committee of Shanghai Municipality (No. 12ZR1441600) and Outstanding Youth Grant from Shanghai Municipal Commission of Health and Family Planning (No. XYQ2013107) to Jun Zhang. Xiaoqin Wang kindly provided statistical advice for this manuscript. Institutional Review Board approval was obtained. Written informed consent was waived by the Institutional Review Board. Methodology: retrospective, experimental, performed at one institution.

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    Authors and Affiliations

    1. Department of Radiology, Huashan Hospital of Fudan University, No. 12 the Middle Wu Lu Mu Qi Road, Shanghai, 200040, China

      Ji Xiong, Jianbo Wen, Jiawei Pan, Jun Zhang & Daoying Geng

    2. Department of Neuropathology, Huashan Hospital of Fudan University, Shanghai, China

      Ji Xiong & Yin Wang

    3. Department of Radiology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China

      Wenli Tan

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    1. Ji Xiong
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    Ji Xiong and Wenli Tan contributed equally to this work.

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    Xiong, J., Tan, W., Wen, J. et al. Combination of diffusion tensor imaging and conventional MRI correlates with isocitrate dehydrogenase 1/2 mutations but not 1p/19q genotyping in oligodendroglial tumours. Eur Radiol 26, 1705–1715 (2016). https://doi.org/10.1007/s00330-015-4025-4

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