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Mutant IDH1-specific immunohistochemistry distinguishes diffuse astrocytoma from astrocytosis

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References

  1. Balss J, Meyer J, Mueller W et al (2008) Analysis of the IDH1 codon 132 mutation in brain tumors. Acta Neuropathol 116:597–602

    Article  CAS  PubMed  Google Scholar 

  2. Bleeker FE, Lamba S, Leenstra S et al (2009) IDH1 mutations at residue p.R132 (IDH1(R132)) occur frequently in high-grade gliomas but not in other solid tumors. Hum Mutat 30:7–11

    Article  CAS  PubMed  Google Scholar 

  3. Bruner JM, Saya H, Moser RP (1991) Immunocytochemical detection of p53 in human gliomas. Mod Pathol 4:671–674

    CAS  PubMed  Google Scholar 

  4. Capper D, Zentgraf H, Balss J et al (2009) Monoclonal antibody specific for IDH1 R132H mutation. Acta Neuropathol 118:599–601

    Article  CAS  PubMed  Google Scholar 

  5. Hartmann C, Meyer J, Balss J et al (2009) Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas. Acta Neuropathol 118:469–474

    Article  PubMed  Google Scholar 

  6. Horbinski C, Kofler J, Kelly LM et al (2009) Diagnostic use of IDH1/2 mutation analysis in routine clinical testing of formalin-fixed, paraffin-embedded glioma tissues. J Neuropathol Exp Neurol 68:1319–1325

    Article  CAS  PubMed  Google Scholar 

  7. Ichimura K, Pearson DM, Kocialkowski S et al (2009) IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas. Neuro Oncol 11:341–347

    Article  CAS  PubMed  Google Scholar 

  8. Lammie GA, Beckett A, Courtney R et al (1994) An immunohistochemical study of p53 and proliferating cell nuclear antigen expression in progressive multifocal leukoencephalopathy. Acta Neuropathol 88:465–471

    Article  CAS  PubMed  Google Scholar 

  9. Louis DN (1994) The p53 gene and protein in human brain tumors. J Neuropathol Exp Neurol 53:11–21

    Article  CAS  PubMed  Google Scholar 

  10. Parsons DW, Jones S, Zhang X et al (2008) An integrated genomic analysis of human glioblastoma multiforme. Science 321:1807–1812

    Article  CAS  PubMed  Google Scholar 

  11. Watanabe T, Nobusawa S, Kleihues P et al (2009) IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas. Am J Pathol 174:1149–1153

    Article  CAS  PubMed  Google Scholar 

  12. Yan H, Parsons DW, Jin G et al (2009) IDH1 and IDH2 mutations in gliomas. N Engl J Med 360:765–773

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

The authors thank Andreas von Deimling and the Deutsches Krebsforschungszentrum (DKFZ; German Cancer Research Center), Germany for providing the R132H-mutant IDH1 antibody. This work was supported by NIH CA57683 (DNL).

Conflict of interest statement

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Boston, MA, USA

    Sandra Camelo-Piragua, Michael Jansen, Aniruddha Ganguly, J. ChulMin Kim, David N. Louis & Catherine L. Nutt

  2. Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA

    David N. Louis

  3. Department of Pathology, Harvard Medical School, Boston, MA, USA

    Sandra Camelo-Piragua, David N. Louis & Catherine L. Nutt

  4. Molecular Pathology Unit, Massachusetts General Hospital, CNY 6014, Building 149, Thirteenth Street, Charlestown, MA, 02129, USA

    Catherine L. Nutt

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  1. Sandra Camelo-Piragua
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  2. Michael Jansen
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  3. Aniruddha Ganguly
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  4. J. ChulMin Kim
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  5. David N. Louis
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  6. Catherine L. Nutt
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Correspondence to Catherine L. Nutt.

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Camelo-Piragua, S., Jansen, M., Ganguly, A. et al. Mutant IDH1-specific immunohistochemistry distinguishes diffuse astrocytoma from astrocytosis. Acta Neuropathol 119, 509–511 (2010). https://doi.org/10.1007/s00401-009-0632-y

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  • DOI: https://doi.org/10.1007/s00401-009-0632-y

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