Skip to main content
Log in

Endoscopic endonasal skull base surgery: past, present and future

  • Review Article
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Endoscopic techniques have undergone tremendous advancement in the past years. From the management of phlogistic pathologies, we have learned to manage skull base lesions and even selected intracranial diseases. Current anatomical knowledge plus computer-aided surgery has enabled surgeons to remove large lesions in the paranasal sinuses extending beyond the boundaries of the sinuses themselves. In this sense, management of benign diseases via endoscopic routes is nowadays well accepted whilst the role of endoscopic techniques in sinonasal malignancies is still under investigation. Nowadays, it is possible to tackle different pathologies placed not only in the ventral skull base, but also extended laterally (infratemporal fossa and petrous apex) and even, in really selected cases, within the orbit. The ability to resect and reconstruct has improved significantly. At the moment, the improvement in surgical techniques, like the four-handed technique, has rendered endoscopic procedures capable of managing complex pathologies, according the same surgical principles of the open approaches. From now onwards, frameless neuronavigation, modular approaches, intraoperative imaging systems and robotic surgery are and will be an increasingly important part of endonasal surgery, and they will be overtaken by further evolution.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10

Similar content being viewed by others

References

  1. Cappabianca P, Alfieri A, de Divitiis E (1998) Endoscopic endonasal transsphenoidal approach to the sella: towards functional endoscopic pituitary surgery (FEPS). Minim Invasive Neurosurg 41:66–73

    Article  CAS  PubMed  Google Scholar 

  2. Heermann H (1958) Ber endonasale Chirugie unter Verwendung des binocularen Mikroskopes. Arch OHR Nase Kehlk Heilk 171:295–297

    Article  CAS  Google Scholar 

  3. Doglietto F, Prevedello DM, Jane JA Jr, Han J, Laws ER Jr (2005) Brief history of endoscopic transphenoidal surgery-from Philipp Bozzini to the First World Congress of endoscopic skull base surgery. Neurosurg Focus 19(6):E3

    Article  PubMed  Google Scholar 

  4. Messerklinger W (1969) The normal secretion ways in the human nose. Arch Klin Exp Ohren Nasen Kehlkopfheilkd 195:138–151

    Article  CAS  PubMed  Google Scholar 

  5. Messerklinger W (1973) Endoscopic anatomy of the human ethmoturbinals. Acta Otolaryngol 75:243–248

    Article  CAS  PubMed  Google Scholar 

  6. Wigand ME, Steiner W (1977) Endonasal antrostomy with endoscopic control for chronic maxillary sinusitis. Laryngol Rhinol Otol (Stuttg) 56:421–425

    CAS  Google Scholar 

  7. Draf W (1978) Therapeutic endoscopy of the paranasal sinuses. Endoscopy 10:247–254

    Article  CAS  PubMed  Google Scholar 

  8. Stammberger H (1985) Personal endoscopic operative technic for the lateral nasal wall–an endoscopic surgery concept in the treatment of inflammatory diseases of the paranasal sinuses. Laryngol Rhinol Otol 64(11):559–566

    Article  CAS  Google Scholar 

  9. Kennedy DW (1985) Functional endoscopic sinus surgery technique. Arch Otolaryngol 111:643–649

    CAS  PubMed  Google Scholar 

  10. Lund VJ, Lloyd GA (1983) Radiological changes associated with benign nasal polyps. J Laryngol Otol 97(6):503–510

    Article  CAS  PubMed  Google Scholar 

  11. Dandy WE (1926) Pneumocephalus (intracranial pneumatocoele or aerocoele). Arch Surg 12:949–982

    Google Scholar 

  12. Dohlman G (1948) Spontaneous cerebrospinal rhinorrhea. Acta Otolaryngol Suppl (Stockh) 67:20–23

    Article  CAS  Google Scholar 

  13. Hirsch O (1952) Successful closure of cerebrospinal fluid leak rhinorrhea by endonasal surgery. AMA Arch Otolaryngol 56:1–12

    CAS  PubMed  Google Scholar 

  14. Wigand ME (1981) Transnasal ethmoidectomy under endoscopic control. Rhinology 19:7–15

    CAS  PubMed  Google Scholar 

  15. Lanza DC, O’Brien DA, Kennedy DW (1996) Endoscopic repair of cerebrospinal fluid fistulae and encephaloceles. Laryngoscope 106:1119–1125

    Article  CAS  PubMed  Google Scholar 

  16. Martin TJ, Loehrl TA (2007) Endoscopic CSF leak repair. Curr Opin Otolaryngol Head Neck Surg 15:35–39

    Article  PubMed  Google Scholar 

  17. Castelnuovo P, Dallan I, Pistochini A, Battaglia P, Locatelli D, Bignami M (2007) Endonasal endoscopic repair of sternberg’s canal cerebrospinal fluid leaks. Laryngoscope 117:345–349

    Article  PubMed  Google Scholar 

  18. Stamm AC, Pignatari SSN, Vellutini E (2006) Transnasal endoscopic surgical approaches to the clivus. Otolaryngol Clin N Am 39:639–656

    Article  Google Scholar 

  19. Castelnuovo P, Dallan I, Bignami M, Pistochini A, Battaglia P, Tschabitscher M (2008) Endoscopic endonasal management of petroclival cerebrospinal fluid leaks: anatomical study and preliminary clinical experience. Minim Invasive Neurosurg 51(6):336–339

    Article  CAS  PubMed  Google Scholar 

  20. Castelnuovo P, Bignami M, Pistochini A, Battaglia P, Locatelli D, Dallan I (2009) Endoscopic endonasal management of encephaloceles in children: an eight-year experience. Int J Pediatr Otorhinolaryngol May 28 [Epub ahead of print]

  21. Dollinger J (1911) Die drickentlastung der augenhokle durch entfernung der ausseren orbitalwand bei hochgradigen exophthalmus und koneskutwer hornhauter kronkkung. Dtsch Med Wochenschr 37:1888

    Article  Google Scholar 

  22. Sewell EC (1936) Operative control of progressive exophthalmosis. Arch Otolaryngol Head Neck Surg 24:621

    Google Scholar 

  23. Hirsch O (1950) Surgical decompression for malignant exophthalmosis. Arch Otolaryngol Head Neck Surg 51:325

    Google Scholar 

  24. Walsh TE, Ogura JH (1957) Transantral orbital decompression for malignant exophthalmos. Laryngoscope 67:544–549

    Article  CAS  PubMed  Google Scholar 

  25. Kennedy DW, Goodstein ML, Miller NR, Zinreich SJ (1990) Endoscopic transnasal orbital decompression. Arch Otolaryngol Head Neck Surg 116:275–282

    CAS  PubMed  Google Scholar 

  26. Michel O, Bresgen K, Russmann W, Thumfart WF, Stennert E (1991) Endoscopically-controlled endonasal orbital decompression in malignant exophthalmos. Laryngorhinootologie 70:656–662

    Article  CAS  PubMed  Google Scholar 

  27. Metson R, Pletcher SD (2006) Endoscopic orbital and optic nerve decompression. Otolaryngol Clin North Am 39:551–561

    Article  PubMed  Google Scholar 

  28. Metson R, Dallow RL, Shore JW (1994) Endoscopic orbital decompression. Laryngoscope 104:950–957

    CAS  PubMed  Google Scholar 

  29. Sellari-Franceschini S, Berrettini S, Santoro A, Nardi M, Mazzeo S, Bartalena L, Mazzi B, Tanda ML, Marcocci C, Pinchera A (2005) Orbital decompression in graves’ ophthalmopathy by medial and lateral wall removal. Otolaryngol Head Neck Surg 133(2):185–189

    Article  PubMed  Google Scholar 

  30. Caldwell GW (1893) Two new operation for the obstruction of nasal duct, with the preservation of the canaliculi and with an incidental description of a new lachrymal probe. Am J Ophtalmol 10:189–193

    Google Scholar 

  31. Toti A (1904) Nuovo metodo conservatore di cura radicale delle suppurazioni croniche del sacco lacrimale (dacriocistorinostomia). Clin Moderna (Firenze) 10:385

    Google Scholar 

  32. McDonogh M, Meiring JH (1989) Endoscopic transnasal dacryocistorhinostomy. J Laryngol Otol 103:585–587

    Article  CAS  PubMed  Google Scholar 

  33. Schloffer H (1907) Erfolgreiche operation eines hypophysen-tumors auf nasalem Wege. Wien Klin Wochenschr 20:621–624

    Google Scholar 

  34. Sethi DS, Leong JL (2006) Endoscopic pituitary surgery. Otolaryngol Clin N Am 39:563–583

    Article  Google Scholar 

  35. Guiot G, Rougerie J, Fourestier M, Fournier A, Comoy C, Vulmiere J, Groux R (1963) Explorations endoscopiques intracrannienes. Press Med 71:1225–1228

    CAS  PubMed  Google Scholar 

  36. Jankowski R, Auque J, Simon C, Marchal JC, Hepner H, Wayhoff M (1992) Endoscopic pituitary tumor surgery. Laryngoscope 102:198–202

    Article  CAS  PubMed  Google Scholar 

  37. Jho HD, Carrau RL (1997) Endoscopic endonasal transsphenoidal surgery: experience with 50 patients. J Neurosurg 87:44–51

    Article  CAS  PubMed  Google Scholar 

  38. De Divitiis E, Cappabianca P, Cavallo LM (2002) Endoscopic transsphenoidal approach: adaptability of the procedure to different sellar lesions. Neurosurgery 51:699–707

    Article  PubMed  Google Scholar 

  39. Frank G, Pasquini E, Farneti G, Mazzatenta D, Sciarretta V, Grasso V, Faustini Fustini M (2006) The endoscopic versus the traditional approach in pituitary surgery. Neuroendocrinology 83(3–4):240–248

    Article  CAS  PubMed  Google Scholar 

  40. Pasquini E, Sciaretta V, Frank G, Cantaroni C, Modugno GC, Mazzatenta D, Farneti G (2004) Endoscopic treatment of benign tumors of the nose and paranasal sinuses. Otolaryngol Head Neck Surg 131(3):180–186

    Article  PubMed  Google Scholar 

  41. Nicolai P, Berlucchi M, Tomenzoli D, Cappiello J, Trimarchi M, Maroldi R, Battaglia G, Antonelli AR (2003) Endoscopic surgery for juvenile angiofibroma: when and how. Laryngoscope 113(5):775–782

    Article  PubMed  Google Scholar 

  42. Bignami M, Dallan I, Terranova P, Battaglia P, Miceli S, Castelnuovo P (2007) Frontal sinus osteomas: the window of endonasal endoscopic approach. Rhinology 45(4):315–320

    PubMed  Google Scholar 

  43. Stammberger H (1981) Zum invertierten Papillom der Nasenschleimhaut. HNO 29:128–133

    CAS  PubMed  Google Scholar 

  44. Tomenzoli D, Castelnuovo P, Pagella F, Berlucchi M, Pianta L, Delù G, Maroldi R, Nicolai P (2004) Different endoscopic surgical strategies in the management of inverted papilloma of the sinonasal tract: experience with 47 patients. Laryngoscope 114(2):193–200

    Article  PubMed  Google Scholar 

  45. Schick B, Steigerwald C, el Tahan A, Draf W (2001) The role of endonasal surgery in the management of frontoethmoidal osteomas. Rhinology 39(2):66–70

    CAS  PubMed  Google Scholar 

  46. Banhiran W, Casiano RR (2005) Endoscopic sinus surgery for benign and malignant nasal and sinus neoplasm. Curr Opin Otolaryngol Head Neck Surg 13:50–54

    Article  PubMed  Google Scholar 

  47. Snyderman CH, Carrau RL, Kassam AB, Zanation A, Prevedello D, Gardner P, Mintz A (2008) Endoscopic skull base surgery: principles of endonasal oncological surgery. J Surg Oncol 97:658–664

    Article  PubMed  Google Scholar 

  48. Nicolai P, Battaglia P, Bignami M, Bolzoni Villaret A, Delù G, Khrais T, Lombardi D, Castelnuovo P (2008) Endoscopic surgery for malignant tumors of the sinonasal tract and adiacent skull base: a 10-year experience. Am J Rhinol 222(3):308–316

    Article  Google Scholar 

  49. Castelnuovo P, Battaglia P, Locatelli D, Delù G, Sberze F, Bignami M (2006) Endonasal micro-endoscopic treatment of malignant tumors of the paranasal sinuses and anterior skull base. Oper Tech Otolaryngol 17:152–167

    Article  Google Scholar 

  50. Fee WE Jr, Robertson JB Jr, Goffinet DR (1991) Long-term survival after surgical resection for recurrent nasopharyngeal cancer after radiotherapy failure. Arch Otolaryngol Head Neck Surg 117(11):1233–1236

    PubMed  Google Scholar 

  51. Yoshizaki T, Wakisaka N, Murono S, Shimizu Y, Furukawa M (2005) Endoscopic nasopharyngectomy for patients with recurrent nasopharyngeal carcinoma at primary site. Laryngoscope 115(8):1517–1519

    Article  PubMed  Google Scholar 

  52. Ko JY, Wang CP, Ting LL, Yang TL, Tan CT (2009) Endoscopic nasopharyngectomy with potassium-titanyl-phosphate (KTP) laser for early locally recurrent nasopharyngeal carcinoma. Head Neck (Epub ahead of print)

  53. Chen MY, Wen WP, Guo X, Yang AK, Qian CN, Hua YJ, Wan XB, Guo ZM, Li TY, Hong MH (2009) Endoscopic nasopharyngectomy for locally recurrent nasopharyngeal carcinoma. Laryngoscope 119(3):516–522

    Article  PubMed  Google Scholar 

  54. Wormald PJ, Robinson S (2006) Transnasal endoscopic resection of benign tumors occurring from or extending into the infratemporal fossa. Op Tech Otolaryngol 17:97–101

    Article  Google Scholar 

  55. Herzallah IR, Germani R, Casiano RR (2009) Endoscopic transnasal study of the infratemporal fossa: a new orientation. Otolaryngol Head Neck Surg 140(6):861–865

    Article  PubMed  Google Scholar 

  56. Dallan I, Bignami M, Battaglia P, Castelnuovo P, Tschabitscher M (2009) Fully endoscopic transnasal approach to the jugular foramen: anatomical study and clinical consideration. Neurosurgery (accepted)

  57. Parkinson D (1965) A surgical approach to the cavernous portion of the carotid artery: anatomical study and case report. J Neurosurg 23:474–483

    Article  CAS  PubMed  Google Scholar 

  58. Gardner PA, Kassam AB, Snyderman CH, Carrau RL, Mintz AH, Grahovac S, Stefko S (2008) Outcome following endoscopic expanded endonasal resection of suprasellar craniopharyngiomas: a case series. J Neurosurg 109:6–16

    Article  PubMed  Google Scholar 

  59. Alfieri A, Jho HD (2001) Endoscopic endonasal approaches to the cavernous sinus: surgical approaches. Neurosurgery 49:354–360

    Article  CAS  PubMed  Google Scholar 

  60. Frank G, Pasquini E (2003) Approach to the cavernous sinus. In: de Divitiis E, Cappabianca P (eds) Endoscopic endonasal transsphenoidal surgery. Springer, Vienna, pp 159–175

    Google Scholar 

  61. Frank G, Sciarretta V, Mazzatenta D, Farneti G, Modugno GC, Pasquini E (2005) Transsphenoidal endoscopic approach in the treatment of Rathke’s cleft cyst. Neurosurgery 56:124–129

    PubMed  Google Scholar 

  62. Stamm AC, Vellutini E, Harvey RJ, Nogeira JF, Herman DR (2008) Endoscopic transnasal craniotomy and the resection of craniopharyngioma. Laryngoscope 118:1142–1148

    Article  PubMed  Google Scholar 

  63. Gardner PA, Kassam AB, Rothfus WE, Snyderman CH, Carrau RL (2008) Preoperative and intraoperative imaging for endoscopic endonasal approaches to the skull base. Otolaryngol Clin N Am 41:215–230

    Article  Google Scholar 

  64. Landolt AM, Zachmann M (1991) Results of transsphenoidal extirpation of craniopharyngiomas and Rathke’s cysts. Neurosurgery 28:410–415

    Article  CAS  PubMed  Google Scholar 

  65. Crockard HA (1985) The transoral approach to the base of the brain and upper cervical cord. Ann R Coll Surg Engl 67:321–325

    CAS  PubMed  Google Scholar 

  66. Draf W, Weber R, Keerl R (1995) Endonasale chirurgie von tumoren der nasennebenhohlen und rhinobasis. Med Bild Dienst 2:13–17

    Google Scholar 

  67. Cappabianca P, Frank G, Pasquini E, de Divitiis O, Calbucci F (2003) Extended endoscopic endonasal transsphenoidal approaches to the suprasellar region, planum sphenoidale and clivus. In: de Divitiis E, Cappabianca P (eds) Endoscopic endonasal transsphenoidal surgery. Springer, Vienna, pp 176–187

    Google Scholar 

  68. Frank G, Pasquini E, Doglietto F, Mazzatenta D, Sciarretta V, Farneti G, Calbucci F (2006) The endoscopic extended transsphenoidal approach for craniopharyngiomas. Neurosurgery 59 (1 Suppl 1):ONS75–ONS83

    Google Scholar 

  69. Snyderman CH, Kassam AB, Carrau RL, Mintz A (2006) Endoscopic approaches to the petrous apex. Op Tech Otolaryngol 17:168–173

    Article  Google Scholar 

  70. Puxeddu R, Lui MWM, Chandrasekar K, Nicolai P, Sekhar L (2002) Endoscopic-assisted transcolummellar approach to the clivus: an anatomical study. Laryngoscope 112:1072–1078

    Article  PubMed  Google Scholar 

  71. Kassam AB, Gardner P, Snyderman C, Mintz AA, Carrau R (2005) Expanded endonasal approach: a fully endoscopic, completely transnasal approach to the middle third of the clivus, petrous bone, middle cranial fossa and infratemporal fossa. Neurosurg Focus 19(1):E6

    PubMed  Google Scholar 

  72. Jho HD, Carrau RL, Mc Laughlin ML, Somaza SC (1996) Endoscopic transsphenoidal resection of a large chordoma in the posterior fossa. Neurosurg Focus 1:1–7

    Google Scholar 

  73. Al-Mefty O, Borba LA (1997) Skull base chordomas: a management challenge. J Neurosurg 86:182–189

    Article  CAS  PubMed  Google Scholar 

  74. Colli B, Al-Mefty O (2001) Chordomas of the craniocervical junction: follow up review and prognostic factors. J Neurosurg 95:933–943

    Article  CAS  PubMed  Google Scholar 

  75. Pamir MN, Kilic T, Ture U, Ozek MM (2004) Multimodality management of 26 skull base chordomas with 4 years mean follow up: experience at a single institution. Acta Neurochir (Wien) 146:343–354

    Article  CAS  Google Scholar 

  76. Alfieri A, Jho HD, Tschabitscher M (2002) Endoscopic endonasal approach to the ventral cranio-cervical junction: anatomical study. Acta Neurochir (Wien) 144:219–225

    Article  CAS  Google Scholar 

  77. Kassam AB, Snyderman C, Gardned P, Carrau R, Spiro R (2005) The expanded endonasal approach: a fully endoscopic transnasal approach and resection of the odontoid process: technical case report. Neurosurgery 57(Suppl 1):ONS213–ONS214

    Google Scholar 

  78. De Almeida JR, Zanation AM, Snyderman CH, Carrau RL, Prevedello DM, Gardner PA, Kassam AB (2009) Defining the nasopalatine line: the limit for endonasal surgery of the spine. Laryngoscope 119(2):239–244

    Article  PubMed  Google Scholar 

  79. Nayak JV, Gardner PA, Vescan AD, Carrau RL, Kassam AB, Snyderman CH (2007) Experience with the expanded endonasal approach for resection of the odontoid process in rheumatoid disease. Am J Rhinol 21(5):601–606

    Article  PubMed  Google Scholar 

  80. Magrini S, Pasquini E, Mazzatenta D, Mascari C, Galassi E, Frank G (2008) Endoscopic endonasal odontoidectomy in a patient affected by Down syndrome: technical case report. Neurosurgery 63(2):E373–E374

    Article  PubMed  Google Scholar 

  81. Wu JC, Huang WC, Cheng H, Liang ML, Ho CY, Wong TT, Shih YH, Yen YS (2008) Endoscopic transnasal transclival odontoidectomy: a new approach to decompression: technical case report. Neurosurgery 63(1 Suppl 1):ONSE92–ONSE94

    Google Scholar 

  82. Leng LZ, Anand VK, Hartl R, Schwartz TH (2009) Endonasal endoscopic resection of an os odontoideum to decompress the cervicomedullary junction: a minimal access surgical technique. Spine 34(4):E139–E143

    Article  PubMed  Google Scholar 

  83. Fernandez-Miranda JC, Gardner PA, Prevedello DM, Kassam AB (2009) Expanded endonasal approach for olfactory groove meningioma. Acta Neurochir (Wien) 151(3):287–288

    Article  CAS  Google Scholar 

  84. De Divitiis E, Cavallo LM, Esposito F, Stella L, Messina A (2008) Extended endoscopic transsphenoidal approach for tuberculum sellae meningiomas. Neurosurgery 62(6 Suppl 3):1192–1201

    PubMed  Google Scholar 

  85. Kassam AB, Mintz AH, Gardner PA, Horowitz MB, Carrau RL, Snyderman CH (2006) The expanded endonasal approach for an endoscopic transnasal clipping and aneurysmorraphy of a large vertebral artery aneurysm: technical case report. Neurosurgery 59(1 Suppl 1):ONSE162–ONSE165

    Google Scholar 

  86. Kassam AB, Gardner PA, Mintz A, Snyderman CH, Carrau RL, Horowitz M (2007) Endoscopic endonasal clipping of an unsecured superior hypophyseal artery aneurysm: technical note. J Neurosurg 107(5):1047–1052

    Article  PubMed  Google Scholar 

  87. O’Malley BW Jr, Weinstein GS (2007) Robotic anterior and midline skull base surgery: preclinical investigations. Int J Radiat Oncol Biol Phys 69(2):S125–S128

    PubMed  Google Scholar 

  88. Hadad G, Bassagasteguy L, Carrau RL, Mataza JC, Kassam AB, Snyderman CH, Mintz A (2006) A novel reconstructive technique after endoscopic expanded endonasal approaches: vascular pedicle nasoseptal flap. Laryngoscope 116:1882–1886

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

All the authors certify that they have no financial relationship with any entity mentioned in the paper. No sponsor is involved in the paper.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Iacopo Dallan.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Castelnuovo, P., Dallan, I., Battaglia, P. et al. Endoscopic endonasal skull base surgery: past, present and future. Eur Arch Otorhinolaryngol 267, 649–663 (2010). https://doi.org/10.1007/s00405-009-1196-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00405-009-1196-0

Keywords

Navigation