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Comparison of experimental aneurysms embolized with second-generation embolic devices and platinum coils

  • Neurovascular Observations
  • Published:
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Abstract

Purpose

The purpose of the study was to compare the performance of second-generation embolic devices with that of platinum coils in experimental aneurysms.

Methods

Microsurgically constructed bifurcation aneurysms in rabbits were embolized with platinum coils (n = 7), HydroCoils 10 (n = 10), HydroSoft (n = 14) or Cerecyte (n = 6) devices. After 1 month, angiographic occlusion was scored and the aneurysms were histologically evaluated by light microscopy. Continuous and ordinal results were compared using ANOVA/Tukey–Kramer HSD and χ2 tests respectively.

Results

Angiographic occlusion at follow-up was increased in the HydroCoil and HydroSoft groups and decreased in the platinum coil and Cerecyte groups. Fibrovascular tissue was observed in the sac of the Cerecyte group, while mixtures of fibrovascular tissue and fibrinous thrombus were observed in the other three groups. The inflammatory response and endothelialization of the neck were similar in all groups.

Conclusions

Expansile hydrogel devices have led to increased progressive occlusion, while degradable polymer devices led to an increased rate of thrombus organization compared with platinum coils.

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Acknowledgements

This study was supported by MicroVention Terumo, Aliso Viejo, CA, USA. We gratefully acknowledge the surgical assistance of Drs. R. Agic, M. Kral, and L. Ritter.

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Authors and Affiliations

  1. Neuroscience Institut Salzburg/Department of Neurology, Christian Doppler Clinic/Paracelsus Medical University, Salzburg, Austria

    Monika Killer & Gunther Ladurner

  2. Department of Neurosurgery, Christian Doppler Clinic/Paracelsus Medical University, Salzburg, Austria

    Thomas Hauser & Bernd Richling

  3. Neuroscience Institut Salzburg, Paracelsus Medical University, Salzburg, Austria

    Andrea Wenger

Authors
  1. Monika Killer
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  2. Thomas Hauser
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  3. Andrea Wenger
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  4. Bernd Richling
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  5. Gunther Ladurner
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Corresponding author

Correspondence to Monika Killer.

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Comment

The authors compare different embolic devices to fill up  brain aneurysms In  an experimental rat model. They demonstrated minor differences between the various devices tested, but the standard platinum coils compared with  expansile  hydrogels and degradable polymers surrounding platinum coils are less efficient. Thus, for neurosurgeons the hydrogel and degradable devices might become the devices of the future.

The weak point in the paper seems to be the histological analysis of the data. The authors stain two-dimensional sections only at the surface and try to deduce the histological composition of the whole tridimensional aneurysm. This is only valuable if the content in the filled aneurysm is homogeneous, which is rather doubtful.

Leo De Ridder

Ghent University, Belgium

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Killer, M., Hauser, T., Wenger, A. et al. Comparison of experimental aneurysms embolized with second-generation embolic devices and platinum coils. Acta Neurochir 151, 497–505 (2009). https://doi.org/10.1007/s00701-009-0237-1

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  • DOI: https://doi.org/10.1007/s00701-009-0237-1

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