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Absolute quantification of perfusion using dynamic susceptibility contrast MRI: pitfalls and possibilities

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Abstract

Absolute quantification of cerebral blood flow, cerebral blood volume and mean transit time is desirable in the determination of tissue viability thresholds and tissue at risk in acute ischaemic stroke, as well as in cases where a global reduction in cerebral blood flow is expected, for example, in patients with dementia or depressive disorders. Absolute values are also useful when comparing sequential examinations of tissue perfusion parameters, for example, in the monitoring and follow-up of various kinds of therapy. Regardless of the method employed, a number of assumptions and approximations must be made to obtain absolute measures of perfusion. Furthermore, the different stages of data acquisition and processing are associated with various degrees of uncertainty. In this review, the problems of particular relevance to absolute quantification of cerebral perfusion parameters using dynamic susceptibility contrast magnetic resonance imaging are discussed, and possible solutions are outlined.

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Authors and Affiliations

  1. Department of Medical Radiation Physics, Lund University, Lund University Hospital, 221 85, Lund, Sweden

    Linda Knutsson, Freddy Ståhlberg & Ronnie Wirestam

  2. Department of Diagnostic Radiology, Lund University, Lund University Hospital, 221 85, Lund, Sweden

    Freddy Ståhlberg

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  1. Linda Knutsson
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Correspondence to Linda Knutsson.

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Knutsson, L., Ståhlberg, F. & Wirestam, R. Absolute quantification of perfusion using dynamic susceptibility contrast MRI: pitfalls and possibilities. Magn Reson Mater Phy 23, 1–21 (2010). https://doi.org/10.1007/s10334-009-0190-2

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  • DOI: https://doi.org/10.1007/s10334-009-0190-2

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