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Brain lymphoma: usefulness of the magnetic resonance spectroscopy

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Abstract

The diagnosis of primary central nervous system lymphoma (PCNSL) should always be considered as an emergency because of the therapeutic consequences it implies. In immunocompetent patients, it relies on stereotactic biopsy. Unfortunately, clinical and radiological features may be misleading and delay the diagnostic procedure. The case we report here illustrates the contribution of magnetic resonance spectroscopy in the diagnostic approach of a very atypical PCNSL.

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References

  1. Baehring JM et al (2003) Neurolymphomatosis. Neuro Oncol 5(2):104–115

    Article  PubMed  Google Scholar 

  2. Beristain X, Azzarelli B (2002) The neurological masquerade of intravascular lymphomatosis. Arch Neurol 59(3):439–443

    Article  PubMed  Google Scholar 

  3. Kim DG et al (1996) Primary central nervous system lymphoma: variety of clinical manifestations and survival. Acta Neurochir (Wien) 138(3):280–289

    Article  CAS  Google Scholar 

  4. Quinones-Hinojosa A et al (2000) Solitary sciatic nerve lymphoma as an initial manifestation of diffuse neurolymphomatosis. Case report and review of the literature. J Neurosurg 92(1):165–169

    Article  PubMed  CAS  Google Scholar 

  5. Shenkier TN (2005) Unusual variants of primary central nervous system lymphoma. Hematol Oncol Clin North Am 19(4):651–664, vi

    Google Scholar 

  6. Singh A et al (1982) Steroid-induced remissions in CNS lymphoma. Neurology 32(11):1267–1271

    PubMed  CAS  Google Scholar 

  7. Al-Yamany M et al (1999) Spontaneous remission of primary central nervous system lymphoma: report of 3 cases and discussion of pathophysiology. J Neurooncol 42(2):151–159

    Article  PubMed  CAS  Google Scholar 

  8. Kon T et al (2003) A primary CNS lymphoma in spontaneous remission for 3.5 years after initial detection of the lesions by MRI. Brain Tumor Pathol 20(1):27–31

    Article  PubMed  Google Scholar 

  9. Rubin M et al (1987) Spontaneous temporary remission in primary CNS lymphoma. Can J Neurol Sci 14(2):175–177

    PubMed  CAS  Google Scholar 

  10. DeAngelis LM et al (1990) Primary CNS lymphoma: combined treatment with chemotherapy and radiotherapy. Neurology 40(1):80–86

    PubMed  CAS  Google Scholar 

  11. DeAngelis LM (1990) Primary central nervous system lymphoma imitates multiple sclerosis. J Neurooncol 9(2):177–181

    Article  PubMed  CAS  Google Scholar 

  12. Lucchinetti C et al (2000) Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol 47(6):707–717

    Article  PubMed  CAS  Google Scholar 

  13. Lach B, Atack E, Hylton D (1985) Clinical and pathological analysis of primary lymphomas of the brain: association of tumors with demyelinative leukoencephalopathy. Neuropathology Exp Neurol 44(309)

  14. Murphy JK, O’Brien CJ, Ironside JW (1989) Morphologic and immunophenotypic characterization of primary brain lymphomas using paraffin-embedded tissue. Histopathology 15(5):449–460

    Article  PubMed  CAS  Google Scholar 

  15. Ducreux D et al (2003) Diffusion-weighted imaging and single-voxel MR spectroscopy in a case of malignant cerebral lymphoma. Neuroradiology 45(12):865–868

    Article  PubMed  CAS  Google Scholar 

  16. Moller-Hartmann W et al (2002) Clinical application of proton magnetic resonance spectroscopy in the diagnosis of intracranial mass lesions. Neuroradiology 44(5):371–381

    Article  PubMed  CAS  Google Scholar 

  17. Hsu EW, Aiken NR, Blackband SJ (1996) Nuclear magnetic resonance microscopy of single neurons under hypotonic perturbation. Am J Physiol 271(6 Pt 1):C1895–C1900

    PubMed  CAS  Google Scholar 

  18. Nelson SJ et al (2002) In vivo molecular imaging for planning radiation therapy of gliomas: an application of 1H MRSI. J Magn Reson Imaging 16(4):464–476

    Article  PubMed  Google Scholar 

  19. Harting I et al (2003) Differentiating primary central nervous system lymphoma from glioma in humans using localised proton magnetic resonance spectroscopy. Neurosci Lett 342(3):163–166

    Article  PubMed  CAS  Google Scholar 

  20. Buhring U et al (2001) MRI features of primary central nervous system lymphomas at presentation. Neurology 57(3):393–396

    PubMed  CAS  Google Scholar 

  21. Kuhlmann T et al (2001) Diagnosis of a multifocal B cell lymphoma with preceding demyelinating central nervous system lesions by single voxel proton MR spectroscopy. J Neurol Neurosurg Psychiatry 70(2):259–262

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Rémy Guillevin.

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Taillibert, S., Guillevin, R., Menuel, C. et al. Brain lymphoma: usefulness of the magnetic resonance spectroscopy. J Neurooncol 86, 225–229 (2008). https://doi.org/10.1007/s11060-007-9468-2

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  • DOI: https://doi.org/10.1007/s11060-007-9468-2

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