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Treatment induced necrosis versus recurrent/progressing brain tumor: going beyond the boundaries of conventional morphologic imaging

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Abstract

Brain tumor patients undergo various combinations therapies, leading to very complex and confusing imaging appearances on follow up MR imaging and hence, differentiating recurrent or progressing tumors from treatment induced necrosis or effects has always been a challenge in neuro-oncologic imaging. This particular topic has become more relevant these days because of the advent of newer anti-angiogenic and anti-neoplastic chemotherapeutic agents as well as use of salvage radiation therapy. Various clinically available functional imaging modalities can provide additional physiologic and metabolic information about the tumors which could be useful in identifying viable tumor from treatment induced necrosis and hence, can guide treatment planning. In this review we will discuss various functional neuro-imaging modalities, their advantages and limitations and also their utility in treatment planning.

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Authors and Affiliations

  1. Division of Neuroradiology, Department of Radiology, Henry Ford Hospital, Detroit, MI, USA

    Rajan Jain, Jayant Narang, David Hearshen & Sona Saksena

  2. Division of Neuroradiology, Department of Radiology, Henry Ford Health System, 2799 West Grand Blvd, Detroit, MI, 48202, USA

    Rajan Jain

  3. Department of Radiology, University of Michigan Hospital, Ann Arbor, MI, USA

    Pia M. Sundgren

  4. Department of Neurosurgery, Henry Ford Hospital, Detroit, MI, USA

    Jack P. Rock & Tom Mikkelsen

  5. Department of Pathology, Henry Ford Hospital, Detroit, MI, USA

    Jorge Gutierrez

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  1. Rajan Jain
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Correspondence to Rajan Jain.

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Jain, R., Narang, J., Sundgren, P.M. et al. Treatment induced necrosis versus recurrent/progressing brain tumor: going beyond the boundaries of conventional morphologic imaging. J Neurooncol 100, 17–29 (2010). https://doi.org/10.1007/s11060-010-0139-3

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