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Ensemble average propagator-based detection of microstructural alterations after stroke

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International Journal of Computer Assisted Radiology and Surgery Aims and scope Submit manuscript

Abstract

Purpose

New analytical reconstruction techniques of diffusion weighted signal have been proposed. A previous work evidenced the exploitability of some indices derived from the simple harmonic oscillator-based reconstruction and estimation (3D-SHORE) model as numerical biomarkers of neural plasticity after stroke. Here, the analysis is extended to two additional indices: return to the plane/origin (RTPP/RTOP) probabilities. Moreover, several motor networks were introduced and the results were analyzed at different time scales.

Methods

Ten patients underwent three diffusion spectrum imaging (DSI) scans [1 week (tp1), 1 month (tp2) and 6 months (tp3) after stroke]. Ten matched controls underwent two DSI scans 1 month apart. 3D-SHORE was used for reconstructing the signal and the microstructural indices were derived. Tract-based analysis was performed along motor cortical, subcortical and transcallosal networks in the contralesional area.

Results

The optimal intra-class correlation coefficient (ICC) was obtained in the subcortical loop for propagator anisotropy (ICC \(=\) 0.96), followed by generalized fractional anisotropy (ICC \(=\) 0.94). The new indices reached the highest stability in the transcallosal network and performed well in the cortical and subcortical networks with the exception of RTOP in the cortical loop (ICC \(=\) 0.59). They allowed discriminating patients from controls at the majority of the timescales. Finally, the regression model using indices calculated along the subcortical loop at tp1 resulted in the best prediction of clinical outcome.

Conclusions

The whole set of microstructural indices provide measurements featuring high precision. The new indices allow discriminating patients from controls in all networks, except for RTPP in the cortical loop. Moreover, the 3D-SHORE indices in subcortical connections constitute a good regression model for predicting the clinical outcome at 6 months, supporting their suitability as numerical biomarkers for neuronal plasticity after stroke.

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Authors and Affiliations

  1. Department of Computer Science, University of Verona, Verona, Italy

    Lorenza Brusini, Silvia Obertino, Mauro Zucchelli & Gloria Menegaz

  2. Institute of Nuclear Medicine, University College of London, London, UK

    Ilaria Boscolo Galazzo

  3. Department of Neuroradiology, University Hospital Verona, Verona, Italy

    Ilaria Boscolo Galazzo

  4. Siemens Healthcare USA, Boston, MA, USA

    Gunnar Krueger

  5. Department of Clinical Neuroscience, CHUV and University of Lausanne, Lausanne, Switzerland

    Cristina Granziera

Authors
  1. Lorenza Brusini
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  2. Silvia Obertino
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  3. Ilaria Boscolo Galazzo
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  4. Mauro Zucchelli
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  5. Gunnar Krueger
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  6. Cristina Granziera
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  7. Gloria Menegaz
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Correspondence to Lorenza Brusini.

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Brusini, L., Obertino, S., Galazzo, I.B. et al. Ensemble average propagator-based detection of microstructural alterations after stroke. Int J CARS 11, 1585–1597 (2016). https://doi.org/10.1007/s11548-016-1442-z

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  • DOI: https://doi.org/10.1007/s11548-016-1442-z

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