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The Role of Chemokines in Mesenchymal Stem Cell Homing to Myocardium

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Abstract

A growing body of preclinical evidence suggests that mesenchymal stem cells (MSCs) are effective for the structural and functional recovery of the infracted heart. Accordingly, clinical trials are underway to determine the benefit of MSC-based therapies. While systemic administration of MSCs is an attractive strategy, and is the route currently used for the administration of MSCs in clinical studies for myocardial infarction, the majority of infused cells do not appear to localize to infracted myocardium in animal studies. Recently, important progress has been made in identifying chemokine receptors critical for the migration and homing of MSCs. Here, we review recent literature regarding mechanisms of MSC homing and recruitment to the ischemic myocardium, and discuss potential influences of low engraftment rates of systemically administered MSCs to the infracted heart tissue on the effects of MSC-based therapies on myocardial infarction.

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Acknowledgements

We thank Xusheng Wang and Ying Zhou for assistances in drawing graphs and collecting data. This work was supported by grants from Natural Science Foundation of China (No. 30871273, 30971496, U1032003) to Y Wu.

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The authors indicate no potential conflicts of interest.

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Authors and Affiliations

  1. Life Science Division, Tsinghua University Graduate School at Shenzhen, Shenzhen, China

    Yaojiong Wu

  2. Center of Excellence in Tissue Engineering, Department of Cell Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China

    Robert C. H. Zhao

  3. Tsinghua University Graduate School at Shenzhen, L406A, Tsinghua Campus, Shenzhen, China

    Yaojiong Wu

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  1. Yaojiong Wu
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  2. Robert C. H. Zhao
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Correspondence to Yaojiong Wu.

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Wu, Y., Zhao, R.C.H. The Role of Chemokines in Mesenchymal Stem Cell Homing to Myocardium. Stem Cell Rev and Rep 8, 243–250 (2012). https://doi.org/10.1007/s12015-011-9293-z

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