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NUT Midline Carcinoma of the Nasal Cavity

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Abstract

Nuclear protein in testis (NUT) midline carcinoma (NMC) is a rare, aggressive, poorly differentiated form of squamous cell carcinoma caused by a chromosomal rearrangement of the NUT gene on chromosome 15. These tumors have a predilection for midline and paramidline structures of the upper aerodigestive tract and mediastinum and can affect patients across a broad age range, including children. In the current example, a 53 year old male presented with a mass originating in the left nasal cavity. The clinical, radiographic, and morphologic features of NMC are discussed.

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Acknowledgments

The authors would like to thank Dr. Chris French and Mr. Adlai Grayson (Brigham and Women’s Hospital/Harvard Medical School) for performing FISH testing on this case.

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Authors and Affiliations

  1. Head and Neck Pathology, Joint Pathology Center, 606 Stephen Sitter Ave., Silver Spring, MD, 20910-1290, USA

    Robert D. Foss

  2. Navy Medical Center San Diego, 34800 Bob Wilson Dr, San Diego, CA, 92134, USA

    Mia Edgar

  3. Department of Otolaryngology, Walter Reed National Military Medical Center, 8901 Rockville Pike, Bethesda, MD, 20889, USA

    Andria M. Caruso & Esther Kim

Authors
  1. Mia Edgar
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  2. Andria M. Caruso
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  3. Esther Kim
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  4. Robert D. Foss
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Correspondence to Robert D. Foss.

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The authors declare that they have no conflict of interest.

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Disclaimer The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Army, Air Force, Department of Defense nor the U.S. Government.

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Edgar, M., Caruso, A.M., Kim, E. et al. NUT Midline Carcinoma of the Nasal Cavity. Head and Neck Pathol 11, 389–392 (2017). https://doi.org/10.1007/s12105-016-0763-0

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  • DOI: https://doi.org/10.1007/s12105-016-0763-0

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